Fetal Skin Wound Healing

January 2009 in “ Advances in Clinical Chemistry ”

Edward P. Buchanan, Michael T. Longaker, H. Peter Lorenz

Studysummary This review discusses the differences in wound healing between fetal and adult skin, highlighting the potential to uncover genes for scarless repair that could improve adult wound healing.

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research An In Vivo Mouse Excisional Wound Model of Scarless Healing

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This study successfully developed a reproducible mouse model demonstrating fetal scarless wound healing, which may provide insights for minimizing scarring in adults.

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research Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34

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research Confocal Microscopic Analysis of Scarless Repair in the Fetal Rat

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In this study, fetal rat wounds at gestational age 16 days healed without scar formation and resembled normal skin architecture, unlike those at 18 days which resulted in scarring and lack of hair follicles.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

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This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

Differential Expression of Fibromodulin, a Transforming Growth Factor-Beta Modulator, in Fetal Skin Development and Scarless Repair

research Differential Expression of Fibromodulin, a Transforming Growth Factor-Beta Modulator, in Fetal Skin Development and Scarless Repair

168 citations , August 2000 in “American Journal of Pathology”

This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.