Thou Shall Not Heal: Overcoming the Non-Healing Behaviour of Diabetic Foot Ulcers by Engineering the Inflammatory Microenvironment

    October 2023 in “ Advanced Drug Delivery Reviews ”
    Michael G. Monaghan, Rajiv Borah, Charlotte Thomsen, S. Browne
    Studysummary This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 7

    1. MSC-Derived sEV-Loaded Hyaluronan Hydrogel Promotes Scarless Skin Healing by Immunomodulation in a Large Skin Wound Model Biomedical Materials · 2022
    2. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021
    3. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    4. Injectable Gelatin Microspheres Loaded with Platelet Rich Plasma Improve Wound Healing by Regulating Early Inflammation International Journal of Medical Sciences · 2021
    5. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020
    6. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    7. Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018