66-Year-Old Female with Itchy Scalp and Hair Loss

    January 2022 in “ Clinical Cases in Dermatology ”
    Mara Ernst, Jennifer Viola, Suchita Sampath, Shannon C. Trotter
    TLDR A woman has a permanent hair loss condition treated with steroids and new medicines, but hair might not regrow.
    Lichen planopilaris (LPP) is a type of cicatricial alopecia leading to permanent hair loss, predominantly affecting Caucasian and Indian women. It has several subtypes, including classic, frontal fibrosing, and Graham-Little-Piccardi-Lasseur, each targeting different scalp areas. The pathogenesis involves upregulation of cell-mediated immunity and JAK expression, causing follicular destruction. Treatments aim to halt scarring, with first-line options being topical and intralesional corticosteroids. Novel treatments like pioglitazone and tofacitinib show promise based on case studies. Patients should be informed that regrowth of destroyed follicles may not be possible, and mental health impacts should be considered in treatment planning.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  99 upvotes 1 month ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  54 upvotes 1 month ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 7 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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