Nail Changes in Alopecia Areata: An Update and Review

January 2018 in “ International Journal of Dermatology ”

Khatiya Chelidze, Shari R. Lipner

alopecia areata nail changes pitting trachyonychia red spotted lunulae onycholysis punctate leukonychia AA

Studysummary This review explores nail changes associated with alopecia areata, noting their prevalence and impact on appearance and function, but reports no new clinical findings; the authors call for larger controlled trials.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Recovery of Nail Dystrophy: Potential New Therapeutic Indication of Tofacitinib

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This report suggests that tofacitinib may be beneficial for patients with nail disease unresponsive to other treatments.

research Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report

26 citations , October 2016 in “Case Reports in Dermatology”

In this study, tofacitinib treatment in a male patient with alopecia areata led to significant hair regrowth and improvement in nail dystrophy symptoms, restoring finger function within 10 months.

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

41 citations , December 2015 in “JAMA Dermatology”

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

research Long-Term Follow-Up of Pediatric Trachyonychia

21 citations , December 2014 in “Pediatric Dermatology”

The researchers reported that most cases of pediatric trachyonychia improved over time without regard to treatment type, based on follow-up with 11 children.

research Severe Onycholysis in a Card Illusionist with Alopecia Areata Universalis

10 citations , January 2013 in “International Journal of Trichology”

This report describes a 23-year-old man with alopecia areata universalis who experienced severe nail abnormalities, which improved with systemic steroids, benefiting his work as a card illusionist.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Vitamin D Concentrations Are Decreased in Patients with Alopecia Areata

54 citations , January 2012 in “Vitamins & Trace Elements”

This study found significantly lower serum vitamin D concentrations in patients with alopecia areata compared to healthy controls, suggesting that vitamin D deficiency may be a risk factor for this autoimmune hair loss disease.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege

139 citations , October 2005 in “Journal of Investigative Dermatology”

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations , August 2005 in “Autoimmunity Reviews”

This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.

research Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata

141 citations , February 2005 in “Journal of the American Academy of Dermatology”

In this study, oral prednisolone pulse therapy led to significant hair regrowth in some patients with extensive alopecia areata, whereas no improvement was seen in the placebo group.

research The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians

275 citations , November 2002 in “International Journal of Dermatology”

This study found that among an Asian population with alopecia areata, commonly first episodes occurred before age 40, with severe cases linked to psychological effects and treatments showing significant regrowth.

research The Spotted Lunula: Three Patients with Alopecia Areata Exhibited Spotty Absence of Whiteness in the Lunulae of Their Nails

30 citations , May 1980 in “Journal of the American Academy of Dermatology”

In this study, three patients with alopecia areata exhibited spotty absence of the whiteness of their nail lunulae, potentially due to defects in the matrical epithelium.

research Twenty-Nail Dystrophy of Alopecia Areata

44 citations , May 1980 in “Archives of Dermatology”

This case study discusses a patient with persistent 20-nail dystrophy following alopecia areata, suggesting that "20-nail dystrophy" describes a condition with multiple potential causes.