Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

October 2009 in “ Journal of Investigative Dermatology ”

Melanie Samson, Fernand Labrie, Christos C. Zouboulis, Van Luu-The

dihydrotestosterone DHT dehydroepiandrosterone DHEA SZ95 sebaceous gland cells testosterone 5α-reductase 4-androstenedione 4-dione 5α-androstane-3,17-dione 5α-dione finasteride androgen-sensitive skin conditions sebaceous gland cells 5-alpha-reductase 5-alpha-dione Propecia

From the encyclopedia

dehydroepiandrosterone →

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.

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Research cited in this study

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research Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes In Vitro

24 citations , February 2007 in “Hormone and metabolic research”

This study suggests that inhibiting 5α-reductase activity alone, particularly with the type 1 inhibitor MK386, may not effectively reduce sebocyte activity or improve acne.

research Sexual Hormones in Human Skin

305 citations , February 2007 in “Hormone and metabolic research”

This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations , January 2004 in “Hormones”

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives

233 citations , November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.

research Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

196 citations , May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.

research Intracrinology and the Skin

82 citations , January 2000 in “Hormone Research in Paediatrics”

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

research Evidence of Heterogeneity and Quantitative Differences of the Type 1 5α-Reductase Expression in Cultured Human Skin Cells: Evidence of Its Presence in Melanocytes

83 citations , January 1998 in “Journal of Investigative Dermatology”

In this study using human cell cultures, type 1 5α-reductase was found to vary in both protein heterogeneity and expression levels across different types of skin cells.