Association Study Reveals a Susceptibility Locus With Male Pattern Baldness in the Han Chinese Population

September 2024 in “ Frontiers in Genetics ”

Li Yang, Huang He, Bo Liang, Feng-Li Xiao, Fusheng Zhou, Xiaodong Zheng, Sen Yang, Xuejun Zhang

male pattern baldness SNP rs13405699 2q31.1 CDCA7 SP3 TGF-β signaling pathway apoptosis MPB single nucleotide polymorphism transforming growth factor beta

Studysummary In this study, researchers found a significant association between the rs13405699 SNP at 2q31.1 and male pattern baldness among Han Chinese men, suggesting genetic influence on this condition in this population.

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This study on Han Chinese men identifies the SNP rs13405699 at 2q31.1 as significantly associated with male pattern baldness (MPB), with a p-value of 4.84 × 10−5 and an odds ratio of 1.37, suggesting a potential genetic locus for MPB susceptibility in this population. The study involved 499 cases and 1,489 controls, and highlights the importance of considering ethnic-specific genetic factors in MPB research. The SNP is located near genes CDCA7 and SP3, which may influence MPB through the TGF-β signaling pathway and apoptosis. The study calls for further research with larger sample sizes to confirm these findings.

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