Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy

    March 2015 in “ Cell death and differentiation ”
    Lior Golomb, Adi Sagiv, Ioannis S. Pateras … Arie Ben‐Yehuda
    Studysummary This study found that H-Ras activation in aged mouse skin leads to increased dysplasia and progression to in situ squamous cell carcinoma, highlighting an age-linked connection between immune changes, senescence, and cancer risk.
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    Research cited in this study 3

    1. Tracing the Cellular Origin of Cancer Nature Cell Biology · 2013
    2. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    3. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011