Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents
August 2026
pigmented human epidermal equivalent melanocytes 3D human skin equivalents single-cell RNA sequencing neonatal foreskin epidermis fibroblast-containing human skin equivalent differentiated cells cell state transition L1CAM-EZR signaling network melanocyte-to-keratinocyte communication epidermal differentiation pigmented skin model skin equivalents RNA sequencing skin differentiation
Studysummary This study utilized a pigmented human epidermal equivalent model to incorporate melanocytes into the epidermis and found enhanced differentiation potential compared to conventional in vitro systems, reflecting in vivo cellular trajectories and highlighting melanocyte-to-keratinocyte communication pathways.
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