Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

June 1997 in “ PubMed ”

Laura A. Hansen, Natalie Alexander, Margaret E. Hogan, John P. Sundberg, Andrzej A. Dlugosz, David W. Threadgill, Terry Magnuson, Stuart H. Yuspa

epidermal growth factor receptor EGFR hair follicle anagen telogen hair loss inflammation interfollicular epidermis hyperplasia epidermal proliferation EGFR hair follicle hair loss inflammation skin cell growth

Studysummary In this study, disrupting the epidermal growth factor receptor in mice led to abnormal hair and skin development, characterized by disorganized hair follicles and systemic disease, providing a model for understanding EGFR's role in skin biology.

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research Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

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