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February 2011 in “Journal of Investigative Dermatology”

New findings suggest targeting IL-23 could treat psoriasis, skin cells can adapt to new roles, direct conversion of skin cells to blood cells may aid cell therapy, removing certain tumor cells could boost cancer immunotherapy, and melanoma may have many tumorigenic cells, not just cancer stem cells.

research Role of the Wnt Signaling Pathway in Keratoacanthoma

2 citations, November 2019 in “Cancer reports”

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

57 citations, March 2018 in “International Journal of Molecular Sciences”

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications

1 citations, March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells

37 citations, November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

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community ‘Long term use of fin/dut may be associated with health risks including fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease and potential kidney disease.’

in Research/Science 22 upvotes 4 months ago

Long-term use of finasteride and dutasteride may be linked to health risks like fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease, and potential kidney disease. Some users believe the risks are low and the medications are generally safe.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 40 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 90 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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