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    Did you mean 5-alpha-reductase inhibitors?
    Glossary5α-reductase inhibitors

    block enzyme converting testosterone to hair-loss-causing DHT

    5α-reductase inhibitors, also known as 5-ARIs, are medications that block the enzyme 5α-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), a hormone that can contribute to conditions like male pattern baldness and benign prostatic hyperplasia (BPH). By inhibiting this enzyme, 5-ARIs can help reduce hair loss and shrink an enlarged prostate.

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      community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

      in Chat 2 years ago
      This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

      community Comparing the effect of T suppression and DHT suppression

      in Transgender  89 upvotes 10 months ago
      The conversation discusses the use of 5-alpha-reductase inhibitors like finasteride and dutasteride for hair loss in transgender women, particularly in relation to testosterone suppression. The original poster has been using dutasteride and is considering stopping it due to undetectable testosterone levels.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 8 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.