Change in Hair Growth-Related Gene Expression Profile in Human Isolated Hair Follicles Induced by 5-Alpha Reductase Inhibitors, Dutasteride and Finasteride, in the Presence of Testosterone

January 2019

Toshiki Hatanaka, Zrinka Lulic, Spiro Getsios, Tim Mefo, Cath Booth, Elliott Harrison, Masahiro Yamada, Gary Ong

5-alpha reductase inhibitors dutasteride finasteride testosterone hair growth-related gene expression human isolated hair follicles androgenetic alopecia Propecia Avodart

TLDR Dutasteride and finasteride can change hair growth genes, helping treat hair loss.

The study investigated the effects of 5-alpha reductase inhibitors, dutasteride and finasteride, on hair growth-related gene expression in human isolated hair follicles in the presence of testosterone. The results indicated that both inhibitors significantly altered the expression profiles of genes associated with hair growth. This suggested that these medications could effectively modulate hair follicle biology, potentially offering therapeutic benefits for conditions like androgenetic alopecia.

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