Change in Hair Growth-Related Gene Expression Profile in Human Isolated Hair Follicles Induced by 5-Alpha Reductase Inhibitors, Dutasteride and Finasteride, in the Presence of Testosterone

    January 2019
    Toshiki Hatanaka, Zrinka Lulic, Spiro Getsios, Tim Mefo, Cath Booth, Elliott Harrison, Masahiro Yamada, Gary Ong
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    Dutasteride →

    Heavy duty finasteride that comes with higher risks

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    Frontline, gold standard treatment for combatting androgenic alopecia

    Studysummary This study suggests that 5AR inhibitors may reverse decreased expression of growth factor genes in human hair follicles under testosterone stimulation, indicating involvement of type I 5AR in hair growth. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the effects of 5-alpha reductase inhibitors, dutasteride and finasteride, on hair growth-related gene expression in human isolated hair follicles in the presence of testosterone. The results indicated that both inhibitors significantly altered the expression profiles of genes associated with hair growth. This suggested that these medications could effectively modulate hair follicle biology, potentially offering therapeutic benefits for conditions like androgenetic alopecia.
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