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Glossary Systemic Medications

drugs that affect the entire body via bloodstream

Systemic medications are drugs that work throughout the entire body rather than targeting a specific area. They are often taken orally or injected, allowing the active ingredients to enter the bloodstream and reach various tissues and organs. This type of treatment is commonly used for conditions that affect multiple parts of the body, such as autoimmune diseases or widespread infections.

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Research

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Adherence Patterns to Medications and Their Association with Subsequent Hospitalization in Adult Egyptian Patients with Systemic Lupus Erythematosus

research Adherence patterns to medications and their association with subsequent hospitalization in adult Egyptian patients with systemic lupus erythematosus

August 2023 in “Lupus”

In this study conducted at an Egyptian outpatient clinic, researchers found that systemic lupus erythematosus patients who were non-adherent to medication had a higher rate of hospitalization and more clinical symptoms compared to those who adhered to their prescribed treatments.

research Infertility and teratogenicity after paternal exposure to systemic dermatologic medications: A systematic review

18 citations , October 2018 in “Journal of The American Academy of Dermatology”

This review indicates that many former FDA category D and X systemic dermatologic medications may negatively impact male fertility, with further research needed to assess potential teratogenic effects.

research Effects of local and systemic medications on eye health: Adverse reactions

January 2025 in “Hospital Pharmacology - International Multidisciplinary Journal”

In this study, researchers explored the effects of various medications on eye health, noting that systemic and local ophthalmic drugs can lead to both widespread and specific ocular side effects, with serious adverse events most associated with neurotropic, immunotropic, and antitumor medications.

research Sexual dysfunction in men taking systemic dermatologic medication: A systematic review

11 citations , March 2019 in “Journal of The American Academy of Dermatology”

This review identifies evidence of sexual adverse effects, particularly linked to finasteride, in men using systemic dermatologic medications but reports no new clinical findings.

research Safety Considerations and Monitoring in Patients Treated with Systemic Medications for Acne

10 citations , January 2016 in “Dermatologic Clinics”

This review discusses the side effects and monitoring guidelines for commonly prescribed systemic acne treatments and reports no new clinical findings.

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Community Join

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community Has anyone had success treating androgenic hair loss topically?

4 upvotes 3 months ago

A woman with androgenic hair loss, likely due to PCOS, is seeking topical treatments as oral medications are not an option. Suggested treatments include topical finasteride, spironolactone, and clascoterone, with spironolactone and clascoterone being safer options due to lower systemic absorption risk.

community If apply topical fin goes systemic then does it matter where I apply it on the scalp?

in Finasteride/Dutasteride 10 upvotes 2 years ago

The conversation is about whether topical finasteride and minoxidil need to be applied directly to the affected areas of the scalp or if they can be spread through blood vessels. It also asks how long topical finasteride remains on a pillow.

community How to minimize RU going systemic?

5 upvotes 4 years ago

An 18-year-old is considering using RU58841 for aggressive hair loss and is also thinking about taking creatine. Users suggest avoiding creatine due to its potential to increase DHT and recommend using topical finasteride instead.

community Has any data on systemic absorption of pyrilutamide been published?

1 upvotes 4 months ago

Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.

community God bless this sub and medications!

732 upvotes 11 months ago

The user achieved significant hair regrowth using 0.5mg oral Dutasteride, 2.5mg oral Minoxidil, topical Minoxidil twice daily, Ketoconazole shampoo twice a week, and weekly dermastamping with no side effects. Results were noticeable after 2-3 months, with the best results at 9 months.

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