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Glossary Small Molecules

low-weight compounds that easily enter cells to regulate processes

Small molecules are low molecular weight organic compounds that can easily enter cells due to their small size. They are often used in medicine to regulate biological processes, including the treatment of diseases like cancer and alopecia, by interacting with specific proteins or enzymes within the body.

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Research

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research Small Molecule Treatments Improve Differentiation Potential of Human Amniotic Fluid Stem Cells

11 citations , February 2021 in “Frontiers in Bioengineering and Biotechnology”

This study suggests that short-term treatments with specific small molecules may enhance the differentiation potential and stem cell properties of human amniotic fluid stem cells.

research A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming

19 citations , December 2018 in “Experimental and Molecular Medicine”

This study reports that the novel small molecule IM176OUT05, by modifying stem cell metabolism, promoted hair regrowth and increased hair follicle numbers in mice.

research 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment

April 2017 in “Journal of Investigative Dermatology”

This study found that SM04755, a novel topical drug, inhibited inflammation, keratinocyte proliferation, and fibrosis in vitro and improved skin health in a mouse model of psoriasis, indicating potential as a topical psoriasis treatment.

research Biologics and small molecules for patients with concomitant alopecia areata and vitiligo: A review

December 2024 in “International Journal of Dermatology”

JAK inhibitors may help treat both alopecia areata and vitiligo, but more research is needed.

research Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles

43 citations , November 2012 in “Pharmaceutical research”

This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.

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Community Join

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community People call companies stupid for making very high concentration Topical Fin solutions but I think they overlook the fact that the actual absorption rate of finasteride varies greatly

in Finasteride/Dutasteride 13 upvotes 2 years ago

The conversation discusses how the absorption rate of topical finasteride varies and is not equivalent to its oral form, with only a small percentage reaching the scalp. It also mentions that minoxidil in high concentrations is used topically because only a small amount is absorbed.

community What is the chance that the pp405 molecule gets leaked to the grey market in phase 3?

18 upvotes 11 months ago

The conversation discusses the potential availability and use of the pp405 molecule for hair loss treatment, with concerns about its legitimacy and safety on the grey market. Participants also mention using products from Umbrella Labs and discuss the concentration and production costs of pp405.

community Should I take creatine if Im on fin?

9 upvotes 1 year ago

Creatine is unlikely to worsen hair loss for those on finasteride, with no strong scientific evidence linking it to increased hair loss. Many users report no negative effects on hair while using creatine.

community UCLA scientists found a molecule — PP405 — that wakes up sleeping hair follicles and tells them, “Do your job.”

1350 upvotes 1 year ago

PP405 is a promising molecule that may reactivate dormant hair follicles, potentially offering a new treatment for hair loss. It is in phase 2 trials, with possible availability between 2027 and 2030.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 2 years ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

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Learn

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learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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Experts

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Clinics

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