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research Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024

8 citations , May 2025 in “Pharmaceuticals”

This article reviews 27 small-molecule drugs approved by the FDA in 2024, noting that among them, eight "first-in-class" drugs with breakthrough therapy status show distinct mechanisms and substantial efficacy improvements in various conditions like cancer and chronic diseases.

research Small molecules and small molecule drugs in regenerative medicine

51 citations , November 2013 in “Drug Discovery Today”

This review discusses the potential applications and challenges of small molecules in regenerative medicine, but it reports no new research findings.

research Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles

43 citations , November 2012 in “Pharmaceutical research”

This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.

A Microscopy-Based Small Molecule Screen in Primary Neurons Reveals Neuroprotective Properties of the FDA-Approved Anti-Viral Drug Elvitegravir

research A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

3 citations , September 2020 in “Molecular Brain”

This study reports that Elvitegravir, a drug currently approved for other uses, shows potential as a neuro- and mitoprotective agent by attenuating mitochondrial damage caused by NMDA receptors in primary mouse cortical neurons.

research The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients

6 citations , March 2023 in “Frontiers in Cellular and Infection Microbiology”

This study found that Golvatinib, Gliquidone, and Dihydroergotamine may inhibit the binding of SARS-CoV-2's Nsp1 protein to the host ribosomal subunit, suggesting potential as treatments against COVID-19 variants.

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community All Drugs in Clinical Trials in 2023

70 upvotes 3 years ago

12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

community Thoughts on new drug PP405? Already reached phase 2

26 upvotes 1 year ago

PP405 is a new drug in Phase 2 trials for hair loss, generating cautious optimism among users. Some users are currently using finasteride and experiencing side effects, while others are skeptical about unapproved products being sold.

community Say this new supposed miracle drug “PP405” does actually cure baldness, how will that affect people with hair transplants?

201 upvotes 1 year ago

PP405 may reactivate dormant hair follicles but won't replace hair transplants or resurrect dead follicles. Its effectiveness, cost, and impact compared to treatments like minoxidil and finasteride are uncertain.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community What is the chance that the pp405 molecule gets leaked to the grey market in phase 3?

18 upvotes 11 months ago

The conversation discusses the potential availability and use of the pp405 molecule for hair loss treatment, with concerns about its legitimacy and safety on the grey market. Participants also mention using products from Umbrella Labs and discuss the concentration and production costs of pp405.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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