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The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

Hair follicles help substances penetrate the skin faster and more effectively.

Mice's intestinal uptake of pantothenic acid is not affected by dietary levels.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Human skin can make serotonin and melatonin.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Sebocytes play a key role in controlling androgen levels in human skin.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Too much androgen can cause hair loss; finasteride may help.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

Four-amino acid part makes enzyme sensitive to finasteride.

Both drugs lower DHT levels, with GI198745 being more effective.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Newly made nicotinamide compounds could potentially treat cancer.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

Compounds from the plant Mammea siamensis may help treat hair loss.