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DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Retinoids are effective for skin conditions like severe acne and psoriasis but must be used with caution due to potential side effects and risks during pregnancy.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Birth control pills help treat skin and hair growth problems linked to high male hormone levels.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Not getting enough minerals can lead to health problems and shorter lifespans.

Plant extracts may help prevent or reverse hair graying.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Vitamin D and its receptor may help prevent skin cancer.

Eating a balanced diet with the right vitamins and minerals is important for healthy hair, but too many supplements can be harmful.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.

Three siblings with a genetic form of rickets showed different symptoms of the disease.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

ΔNp63α helps control a protein that stops cancer cells from spreading.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.