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Trichohyalin is also found in the outer layers of normal human skin.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Prolactin may be important for skin growth and immune function.

Iron deficiency may contribute to hair loss.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

The COVID-19 pandemic led to an increase in untreated hair diseases and showed the importance of teledermatology.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Early diagnosis and treatment are crucial for preventing permanent hair loss in various scalp conditions, and while new treatments are promising, more research is needed to evaluate their effectiveness.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Scalp cooling is the most effective FDA-approved method to prevent chemotherapy-induced hair loss, but more research is needed for other treatments.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Men with common hair loss may have a higher risk of heart disease and diabetes, and should be checked for these conditions.

Bariatric surgery affects skin health, causing both direct complications and changes in existing skin conditions, often related to nutritional deficiencies.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

New resveratrol-related compounds show promise for treating various health issues but need more research for clinical use.

Regenerative therapies show promise for treating vitiligo and alopecia areata.