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    Glossary Vismodegib

    medication treats skin cancer by inhibiting Hedgehog signaling pathway

    Vismodegib is a medication used to treat basal cell carcinoma, a type of skin cancer. It works by inhibiting the Hedgehog signaling pathway, which is involved in the growth and spread of cancer cells. This drug is particularly useful for patients with advanced stages of the disease or those who cannot undergo surgery or radiation.

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    Research 30 of 96

    1. Managing adverse events associated with vismodegib in the treatment of basal cell carcinoma Future oncology · 2016 · 28 citations
    2. A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma Journal of drugs in dermatology · 2021 · 25 citations
    3. Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects Journal of dermatological treatment · 2019 · 8 citations
    4. Adverse events associated with vismodegib: insights from a real-world pharmacovigilance study using the FAERS database Frontiers in Pharmacology · 2025 · 3 citations
    5. Disproportionality analysis comparing safety profiles of sonidegib and vismodegib based on the FAERS database Scientific Reports · 2025 · 1 citations
    6. Unique Tumor Heterogeneity Within a Single Locally Advanced Basal Cell Carcinoma Resulting in Partial Response Despite Continuous Vismodegib Treatment Dermatologic Surgery · 2018 · 1 citations
    7. Experiences with Smo antagonist vismodegib for the treatment of locally advanced basal cell carcinoma 2017
    8. A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy Nature · 2018 · 105 citations
    9. Targeting of Smoothened for therapeutic gain Trends in Pharmacological Sciences · 2014 · 105 citations
    10. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    11. Alopecia in patients treated with molecularly targeted anticancer therapies Annals of Oncology · 2015 · 44 citations
    12. Emerging drugs and combination strategies for basal cell carcinoma Expert opinion on emerging drugs · 2014 · 19 citations
    13. From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots British Journal of Dermatology · 2017 · 17 citations
    14. Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma Clinical Cancer Research · 2015 · 16 citations
    15. Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road Journal of Investigative Dermatology · 2014 · 15 citations
    16. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    17. Hair loss and Hedgehog inhibitors: a class effect? British Journal of Dermatology · 2014 · 9 citations
    18. Abstracts Lasers in Surgery and Medicine · 2023 · 7 citations
    19. Malignant epithelial tumors: Part II. Therapy and prevention Journal der Deutschen Dermatologischen Gesellschaft · 2013 · 5 citations
    20. Scalp basal cell carcinoma: A different entity? Dermatologic Therapy · 2019 · 4 citations
    21. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    22. “Prick or treat”: a case of systemic reaction during intradermal tests with beta-lactams European Journal of Dermatology · 2022 · 1 citations
    23. Adverse Hair Reactions to New Targeted Therapies for Cancer Actas Dermo-Sifiliográficas · 2019 · 1 citations
    24. Cells to Surgery Quiz: December 2017 2017 · 1 citations
    25. Impact of Reporter Type on Signal Detection of Cancer Therapy-Induced Alopecia: A Hypothesis-Generating Study Using the FDA Adverse Event Reporting System Pharmaceuticals · 2026
    26. Impact of Reporter Type on Signal Detection of Cancer Therapy–Induced Alopecia: A Hypothesis-Generating Study Using the FDA Adverse Event Reporting System Preprints.org · 2026
    27. Alopecia due to chemotherapeutics, hedgehog inhibitors, targeted antibody therapies and immune checkpoint inhibitors Deleted Journal · 2024
    28. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    29. Keloid pathogenesis and fibroproliferative properties are dependent on stem cells regulated by the HEDGEHOG-GLI1 pathway Research Square (Research Square) · 2023
    30. Author response: Coordinated hedgehog signaling induces new hair follicles in adult skin 2019