10 citations
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May 2009 in “Cases Journal” This case study reports that a virilizing Leydig cell type ovarian tumor in a 40-year-old woman caused hyperandrogenism and virilization symptoms, which improved post-surgery.
6 citations
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January 2010 in “Case Reports” This study describes the case of a Filipino woman with virilisation, where a rare ovarian Leydig cell tumour was identified and removed, normalizing her testosterone levels.
July 2024 in “Journal of the ASEAN Federation of Endocrine Societies” In this case study, a 69-year-old woman with signs of virilization and high testosterone levels was found to have an ovarian steroid cell tumor, highlighting the importance of systematically investigating such symptoms in postmenopausal women to determine the underlying etiology and prevent poor prognosis.
October 2025 in “Journal of Obstetric and Gynaecological Practices POGS” 2 citations
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July 2023 in “AACE Clinical Case Reports” In this case study, researchers identified a Leydig cell tumor in a 56-year-old postmenopausal woman with virilization symptoms by using ovarian vein sampling, as imaging was nonrevealing, and confirmed the tumor's location using testosterone ratios, which supported previous findings.
December 2022 in “Journal of Medical Case Reports” This case report highlights the importance of considering an ovarian steroid cell tumor diagnosis in young women with increased testosterone after ruling out polycystic ovarian syndrome.
27 citations
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April 2017 in “European journal of endocrinology” This retrospective study found that serum hormone levels and MRI detection of ovarian nodules contributed to distinguishing virilizing ovarian tumors from ovarian stromal hyperthecosis in postmenopausal women, though histopathology remains crucial for diagnosis.
6 citations
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June 2006 in “International Journal of Gynecological Pathology” This study reports that in a case of benign Brenner tumor, elevated androgens may originate from luteinized stromal cells, as these cells do not convert androgen to estrogen due to suppressed aromatase biosynthesis.
April 2023 in “Research Square (Research Square)” This case study of a young Palestinian woman illustrates the diagnostic and treatment challenges of ovarian steroid cell tumors, highlighting the importance of detailed examination when hormonal therapy fails.
20 citations
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October 2017 in “Clinical Endocrinology” This article reviews existing knowledge on postmenopausal hyperandrogenism and highlights diagnostic challenges, reporting no new clinical results.
8 citations
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April 2019 in “Journal of the Endocrine Society” In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.
January 2017 in “University journal of surgery and surgical specialities” This case study describes a rare steroid cell tumor of the ovary in a 42-year-old woman, highlighting its virilizing effects and the importance of thorough follow-up due to its potential for malignancy.
2 citations
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February 2021 in “Endocrinology, diabetes & metabolism case reports” This case report describes a 15-year-old girl with severe hyperandrogenaemia linked to both an ovarian androgen-secreting tumor and HAIR-AN syndrome, highlighting the complexity of diagnosing polycystic ovarian syndrome.
January 2019 in “Skin appendage disorders” This report presents a rare case where a bilateral ovarian thecoma in a postmenopausal woman led to an unusual pattern of female androgenetic alopecia mimicking male pattern hair loss.
1 citations
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January 2018 in “Journal of SAFOMS” This case report describes a postmenopausal woman with a rare instance of ovarian fibrothecoma exhibiting virilizing features, who presented with symptoms such as excess hair growth and clitoromegaly.
April 2023 in “Research Square (Research Square)” This case report highlights a Palestinian woman with a rare ovarian steroid cell tumor, underscoring the diagnostic challenges and potential for disease progression despite treatment attempts with various chemotherapy regimens.
May 2021 in “Journal of the Endocrine Society” This case report describes the rare association of an ovarian Leydig cell tumor and primary hyperparathyroidism in a postmenopausal woman, highlighting the importance of considering rare causes in patients with virilizing symptoms.
September 2024 in “Electronic Journal of General Medicine” In this case series study, two Peruvian women with virilizing ovarian tumors called Sertoli-Leydig cell tumors showed clinical improvement and normalization of androgens after surgical treatment, highlighting the diagnostic challenge of these rare presentations at different ages.
14 citations
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March 2022 in “Clinical Endocrinology” This review outlines a diagnostic approach for identifying non-PCOS pathology in women with androgen excess, emphasizing the importance of clinical history and biochemical phenotyping but reports no new clinical results.
January 2013 in “Obstetrical & gynecological survey” This review discusses diagnostic and management approaches for hirsutism, emphasizing that most cases are due to polycystic ovary syndrome or obesity-related disorders, with idiopathic hirsutism often treated cosmetically.
November 1993 in “PubMed” This review discusses causes and treatments for hirsutism in women and reports no new clinical results.
October 2016 in “Journal of Case Reports” This study reports a case of an ovarian steroid cell tumor with malignant potential, presenting unusually with osteopenia and low weight instead of the expected virilizing symptoms.
May 2025 in “International Journal of Reproduction Contraception Obstetrics and Gynecology” In this case report, the researchers described a postmenopausal woman with androgenic symptoms who was found to have a benign Leydig cell tumor of the left ovary, indicated by elevated testosterone levels and MRI findings, which was successfully treated with surgery.
22 citations
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February 2014 in “Arquivos Brasileiros De Endocrinologia E Metabologia” An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.
June 2026 in “Romanian Journal of Medical Practice” This case report describes a 72-year-old woman with a steroid cell tumor of the ovary, highlighting the critical role of imaging, biochemical evaluation, and pathology in diagnosing and managing hormonally active ovarian tumors that cause virilization in postmenopausal women.
7 citations
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March 2023 in “Gynecological Endocrinology” This study reported a rare case of ovarian steroid cell tumor removal resulting in normalized hormone levels, resumption of menstruation, and subsequent spontaneous pregnancy in a 31-year-old woman.
November 2022 in “Journal of the Endocrine Society” This case report highlights the diagnostic challenge of identifying androgen-secreting ovarian Leydig cell tumors in postmenopausal women when imaging fails to reveal masses, emphasizing the usefulness of ovarian vein sampling for localization.
April 2020 in “Journal of the Endocrine Society” This case report describes a 58-year-old woman whose virilization symptoms were linked to a steroid tumor of the ovary, emphasizing the importance of prompt diagnosis and treatment to improve her quality of life.
August 2025 in “Endokrynologia Polska” A rare pancreatic tumor caused a woman's male-like features, treated successfully with surgery and medication.
May 2025 in “Journal of the ASEAN Federation of Endocrine Societies” This case study reported a 68-year-old woman with postmenopausal virilization due to a rare Sertoli-Leydig cell tumor, where her symptoms and elevated testosterone levels only normalized post-surgery, underscoring the importance of thorough evaluation in such cases to improve diagnosis and treatment.