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    Glossary Uncombable Hair Syndrome

    rare genetic condition causing frizzy, unmanageable hair with unique shaft structure

    Uncombable Hair Syndrome (UHS), also known as Pili Trianguli et Canaliculi or Spun Glass Hair, is a rare genetic condition characterized by dry, frizzy hair that stands out from the scalp and cannot be combed flat. The hair shafts are uniquely structured with a triangular or heart-shaped cross-section and a longitudinal groove, making them resistant to being styled or managed.

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    Research 30 of 147

    1. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    2. Uncombable hair syndrome: Observations on response to biotin and occurrence in siblings with ectodermal dysplasia Journal of the American Academy of Dermatology · 1985 · 101 citations
    3. Familial Uncombable Hair Syndrome: Ultrastructural Hair Study and Response to Biotin Pediatric Dermatology · 2007 · 49 citations
    4. Uncombable-hair Syndrome Pediatric dermatology · 1987 · 12 citations
    5. Hair cross-sectioning in uncombable hair syndrome: An easy tool for complex diagnosis Journal of the American Academy of Dermatology · 2018 · 7 citations
    6. A girl with loose anagen hair syndrome and concurrent uncombable hair syndrome JAAD Case Reports · 2020 · 3 citations
    7. Two siblings with uncombable hair syndrome: A new pathogenic variant Pediatric Dermatology · 2024 · 2 citations
    8. Spontaneous Quick Resolution of Uncombable Hair Syndrome-Like Disease Skin appendage disorders · 2018 · 2 citations
    9. Juleartikel: Tilfælde af uncombable hair syndrome opdaget efter udgivelse af artikel i Ugeskrift for Læger University of Southern Denmark Research Portal (University of Southern Denmark) · 2023
    10. Christmas article: Case of uncombable hair syndrome discovered after publication of article in Ugeskrift for Læger University of Southern Denmark Research Portal (University of Southern Denmark) · 2023
    11. Uncombable hair in a case of Zellweger syndrome – A new association Indian Dermatology Online Journal · 2023
    12. Uncombable hair syndrome due to maternal uniparental disomy of chromosome 1 American journal of medical genetics. Part A · 2022
    13. Uncombable hair syndrome and beyond Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2022
    14. A case of localized uncombable hair syndrome Journal of the American Academy of Dermatology · 2016
    15. Uncombable hair syndrome: A case presentation Journal of the American Academy of Dermatology · 2013
    16. Hair shaft disorders in a child with loose anagen syndrome and uncombable hair: Clues to an underlying genetic disorder Indian Journal of Dermatology Venereology and Leprology · 2026
    17. Uncombable hair (pili trianguli et Canaliculi): Evidence for dominant inheritance with complete penetrance based on scanning electron microscopy American Journal of Medical Genetics · 1987 · 33 citations
    18. Crystalline Cataract and Uncombable Hair Ophthalmology · 1990 · 26 citations
    19. Acquired Uncombable Hair Archives of Dermatology · 1993 · 6 citations
    20. Acquired uncombable hair Archives of Dermatology · 1993 · 2 citations
    21. Uncombable hair improved by biotin JEADV Clinical Practice · 2023
    22. The genetics of hair shaft disorders Journal of The American Academy of Dermatology · 2008 · 59 citations
    23. Unruly hair British Journal of Dermatology · 1985 · 19 citations
    24. Light Microscopic Hair Abnormalities in Children: Retrospective Review of 119 Cases in a 10-Year Period Pediatric and Developmental Pathology · 2013 · 7 citations
    25. Hair microscopy: an easy adjunct to diagnosis of systemic diseases in children Applied Microscopy · 2021 · 3 citations
    26. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    27. Hair and Scalp Dermatoscopy (Trichoscopy) Elsevier eBooks · 2018 · 2 citations
    28. Hair That Is Difficult to Manage in a Hispanic Girl Skin appendage disorders · 2017 · 1 citations
    29. Hair loss in infancy and childhood Paediatrics and Child Health · 2014 · 1 citations
    30. Acquired progressive kinking of the hair in a Korean female adolescent The Journal of Dermatology · 2012 · 1 citations