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Arsenic exposure from contaminated water severely damages the skin, causing hair loss, pigmentation changes, irritation, and can lead to skin cancer.

Targeting the Smoothened receptor shows promise for treating certain cancers.

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.

Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.

EGFR helps control how hair grows and forms without needing p53 protein.

A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

Neomycin is a common cause of follicular contact dermatitis, which is treated by avoiding the allergen and using creams.

The new nanofiber improves wound healing by releasing growth factors, reducing inflammation, and helping skin regeneration.

A new carrier improves skin delivery of tofacitinib for treating inflammatory skin diseases.

Black cumin and its nanoformulations show promise in treating neurodegenerative diseases.

Baby teeth stem cells can potentially grow organs and treat diseases.

The document concludes that specific methods for making diazine-based drugs can lead to high yields and are important for creating effective treatments for various diseases.

The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.