The Promoted Synthesis of Minoxidil by Magnetic Nanoparticles of Cobalt Ferrite (CoFe2O4) as a Heterogeneous Reusable Catalyst

In the 2019 study, researchers successfully synthesized minoxidil using cobalt ferrite (CoFe2O4) magnetic nanoparticles (MNPs) as a catalyst. The MNPs were prepared through a solid-state grinding method and showed high catalytic activity, achieving a 95% yield of minoxidil in 60 minutes using hydrogen peroxide in refluxing ethanol. The catalyst was also reusable for up to six cycles with minimal loss of activity or magnetic properties. This method provides an efficient, cost-effective, and environmentally friendly approach to producing minoxidil with high yield and purity. The catalyst's easy magnetic separation process and the short reaction time further enhance the practicality of this synthesis technique.