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The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Spironolactone treatment increases the amount of testosterone available in the body.

Human skin can make serotonin and melatonin.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

The Rotterdam Study aims to understand various diseases in older adults.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

The cuneate nucleus has two main neuron types: relay neurons and interneurons.

Calcium affects where root hairs grow, but other unknown factors determine their growth direction.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

New effective scar treatments are urgently needed due to the current options' limited success.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Telocytes might help with skin repair and regeneration.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Young adults have about 230,000 tactile nerve fibers, decreasing 5-8% per decade with age.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.