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    Did you mean Transcription Factors?
    Glossary Transcription Factors

    proteins that regulate gene expression by binding to DNA

    Transcription Factors (TFs) are proteins that help turn specific genes on or off by binding to nearby DNA. They play a crucial role in regulating gene expression, ensuring that genes are activated at the right time and in the right cells, which is essential for processes like development, cell growth, and response to environmental signals.

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    1. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis Development · 2011 · 59 citations
    2. Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea Frontiers in Immunology · 2021 · 13 citations
    3. RSL4 regulatory network acts as an early driver of root hair growth at low temperature in Arabidopsis thaliana bioRxiv (Cold Spring Harbor Laboratory) · 2024
    4. A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions Nature Communications · 2025 · 13 citations
    5. Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets Health Science Reports · 2026
    6. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    7. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    8. Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease bioRxiv (Cold Spring Harbor Laboratory) · 2022
    9. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation Differentiation · 2009 · 35 citations
    10. Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype Developmental Dynamics · 2000 · 75 citations
    11. NAC transcription factor RD26 is a regulator of root hair morphogenic plasticity bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    12. LHX2: a transcription factor in development, homeostasis, repair, and disease Frontiers in Cell and Developmental Biology · 2026
    13. Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats International Journal of Molecular Sciences · 2024 · 2 citations
    14. 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes Journal of Investigative Dermatology · 2024
    15. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    16. Network pharmacological study of ethyl acetate fraction of Ophioglossum vulgatum Linn. in alopecia treatment Research Square (Research Square) · 2022
    17. Author response: ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas 2015
    18. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    19. Cell-intrinsic mechanisms governing stem cell quiescence and regulating cancer progression in mammalian skin CU Scholar (University of Colorado Boulder) · 2015
    20. 397 Predictive modeling of drug response and mechanism of action in alopecia areata clinical trials 2017
    21. Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing Microbiology spectrum · 2021 · 8 citations
    22. Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells Journal of Biological Chemistry · 2001 · 8 citations
    23. Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis Human genomics · 2022 · 8 citations
    24. Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis Frontiers in Cell and Developmental Biology · 2025
    25. A computationally inferred regulatory heart aging model including post-transcriptional regulations 2016 · 1 citations
    26. p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis The Journal of Cell Biology · 2011 · 166 citations
    27. Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances Cell Regeneration · 2026
    28. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2 Stem cells · 2012 · 123 citations
    29. Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response during Wound Repair 2022 · 3 citations
    30. PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence Science Advances · 2025