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Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

The document concludes that careful surgical methods and choosing the right materials are key for successful scalp, skull, and frontal sinus reconstruction.

Traditional Chinese medications can cause skin reactions, and better testing and reporting are needed to identify allergens.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Testosterone is crucial for development, growth, and various body functions in mammals.

Choline and biotin are important for liver health and preventing certain deficiencies in animals, and more research is needed to understand their benefits in humans.

Compression therapy improved ankle movement, reduced leg swelling, and lessened pain in patients with venous leg ulcers.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Some drugs have gained approval for new uses, while others like tricyclic antidepressants and aspirin show promise but aren't yet approved for these uses.

Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.

Psychological factors play a significant role in developing alopecia areata.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Different hair evaluation methods have their own pros and cons, and using multiple methods together is best for accurate hair loss diagnosis and tracking.

A girl with rickets and hair loss was found to have a rare condition where her body didn't respond to vitamin D treatment.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Traditional Chinese medicines with heavy metals can cause severe poisoning.

Some psychiatric medications can cause hair loss, but it usually grows back after adjusting the medication.

Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Ectodermal dysplasia causes various symptoms and early treatment is important for eye, dental, and skin issues.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

Rats had lasting erectile problems after stopping a certain medication.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Biotin and inositol are crucial for pig health and growth.