14 citations
,
November 2005 in “Life sciences” This study indicates that vitamin D3 administration may protect rat hair follicles from radiation-induced damage, as evidenced by maintained follicle numbers and increased Vitamin D receptor activity in treated skin.
13 citations
,
July 2017 in “Annals of Oncology” This study suggests that DNA-neutralizing agents like DNAse I and Resveratrol-Cu might reduce chemotherapy-induced toxicity, although this conclusion is based on a small animal study and needs more research.
13 citations
,
December 2013 in “Chemistry Central Journal” This study developed an inexpensive method to provide initial data on both the photostability and toxicity of pure active principles and their photodegradation products.
12 citations
,
December 1962 in “Journal of Investigative Dermatology” 12 citations
,
December 1951 in “Experimental Biology and Medicine” This study found that feeding desiccated whole liver to immature rats on a synthetic diet largely prevented the negative effects of toxic cortisone acetate doses, unlike known B vitamins.
11 citations
,
July 2024 in “Cancers” This review discusses common skin toxicities from cancer treatments and offers management strategies, particularly for regions like Australia and New Zealand with high UV exposure.
11 citations
,
September 2022 in “World Journal of Advanced Pharmaceutical and Medical Research” This review examines the chemical constituents and pharmacological effects of Nicotiana tabacum but reports no new experimental findings, emphasizing traditional uses and known bioactivities.
11 citations
,
February 2002 in “European Journal of Clinical Investigation” This study found that two new platinum complexes significantly extended survival in rats with induced tumors, showing effective antitumor activity without severe toxicity.
10 citations
,
August 2020 in “Drug metabolism and drug interactions” This case series found that patients with the NUDT15 415C>T variant experienced severe azathioprine toxicity, suggesting genotype-based dosing could reduce adverse effects.
10 citations
,
August 2002 in “British Journal of Ophthalmology” This case study reports that intralesional cidofovir was successfully used for treatment without systemic toxicity, suggesting it might be an option worth considering for SCC.
9 citations
,
January 2021 in “Strahlentherapie und Onkologie” This case report suggests that topical St. John's wort oil may cause severe skin toxicity during radiotherapy for non-small cell lung cancer, acting as a significant radiosensitizer.
9 citations
,
December 2018 in “Cutaneous and Ocular Toxicology” This meta-analysis found that combined BRAF and MEK inhibitor treatment in melanoma patients is linked to increased all-grade rash but reduced risks of several other dermatological toxicities compared to BRAF inhibition alone.
7 citations
,
October 2021 in “Journal of Mind and Medical Sciences” This study found that most milk powder samples tested from the Romanian market contained element concentrations exceeding legal limits, especially potassium, calcium, chlorine, phosphorus, and aluminum.
7 citations
,
January 1993 in “Rheumatology” This article discusses suspected skin toxicity from drugs used to treat rheumatoid arthritis but reports no new clinical findings.
6 citations
,
July 1990 in “The Journal of Pediatrics” A boy with toxic shock syndrome had severe heart rhythm problems but recovered with treatment.
5 citations
,
November 2012 in “Journal of Clinical Psychopharmacology” This case report describes an 80-year-old man who developed valproate toxicity and functional decline after starting isoniazid, highlighting a potential drug interaction in elderly patients.
4 citations
,
December 2022 in “Frontiers in cell and developmental biology” This review discusses the use of zebrafish larvae as an alternative model for studying ototoxicity, facilitating large-scale screening for otoprotective compounds, but reports no new clinical results.
4 citations
,
January 2020 in “Skin appendage disorders” This study highlighted that toxic metals, particularly thallium, arsenic, selenium, and mercury, are commonly associated with cases of alopecia areata.
4 citations
,
December 2018 in “Progress in Medical Sciences” This study found that methanol extract of Phoenix dactilifera improved kidney function in rats at doses of 4 and 8 mg/kg, but may impair renal function at 16 mg/kg.
3 citations
,
October 2012 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, pemetrexed combined with cisplatin for advanced NSCLC treatment had similar efficacy to gemcitabine but resulted in significantly fewer adverse reactions.
2 citations
,
January 2018 in “Elsevier eBooks” Targeted therapies for lung cancer are effective but require careful management of side effects to benefit patients.
2 citations
,
June 1985 in “PubMed” This study observed that ethylenthiourea's lethality increases with dose accumulation and ethanol co-administration, while impaired liver function and various adverse effects were noted in long-term treated rats.
1 citations
,
January 2023 in “eCite Digital Repository (University of Tasmania)” This study suggests that the differences in aluminium tolerance between ET8 and ES8 wheat cultivars are linked to a complex suite of physiological mechanisms, including variations in malate and K+ release, Ca2+ homeostasis, and SV channel properties, rather than solely malate efflux.
1 citations
,
January 2023 in “International journal of all research education and scientific methods” This review highlights how forensic drug analysis in hair using modern instrumental techniques offers advantages such as easy sample collection and chronological tracking of drug use, emphasizing its value for law enforcement and other applications.
1 citations
,
February 2020 in “The Journal of clinical investigation/The journal of clinical investigation” This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.
1 citations
,
January 2007 in “The Kitakanto Medical Journal” This report documents a case where a man survived sub-acute toxicity from an overdose of the anticancer drug UFT due to effective treatment with antibiotics and granulocyte colony-stimulating factor.
December 2018 in “Progress in Medical Sciences” This study observed that methanol extract of Phoenix dactilifera improved kidney function in rats at 4 and 8 mg/kg doses, but a 16 mg/kg dose may impair kidney function by affecting urea and potassium excretion.
July 2026 in “Frontiers in Pharmacology” This study assessed pharmacogenomic variants and chemotherapy-related toxicity profiles in Tanzanian children with cancer, reporting notable genetic diversity that may influence toxicity but did not evaluate genotype-toxicity associations.
May 2026 in “Nature Environment and Pollution Technology” This study found that both acute and chronic exposure to nano polystyrene in laboratory rats disrupted hematological function, increased oxidative stress, and led to behavioral and physiological changes, like anemia-like effects and neurological disruptions, suggesting its potential as a cumulative toxicant.
March 2026 in “Critical Care Medicine” This study reports a rare case of refractory status epilepticus in a 48-year-old man after a hair transplant, likely due to neurotoxic effects from combined use of local anesthetics and tranexamic acid, highlighting the importance of early recognition and management of such complications.