Antitumor and Toxic Effects on Wistar Rats of Two New Platinum Complexes

    February 2002 in “ European Journal of Clinical Investigation ”
    Alexandros Charalabopoulos, S. Karkabounas, E. Ioachim, V. Papalimneou, K. Syrigos, Angelos Evangelou, Niki J. Agnantis, Nick Hadjiliadis
    TLDR The new platinum complexes effectively increased survival in rats with tumors, despite some reversible side effects.
    The study investigated the antitumour and toxic effects of two new platinum complexes, Pt(ino)2Cl2 and cis-[Pt(NH3)2(ala)](NO3), on benzo(a)pyrene-induced tumours in Wistar rats. The results showed a significant increase in the mean survival time of the treated rats (272 ± 18 days and 246 ± 26 days) compared to the control group (195 ± 22 days), with a P-value of less than 0.001, indicating strong antitumour activity. Toxic effects observed included a decrease in leucocyte count, mild haemolysis, haematuria, hepatotoxicity, elevated body temperature, and hair loss, all of which were reversible after stopping the treatment. The study concluded that these platinum complexes were effective against tumours with manageable toxicity levels in the tested rats.
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