Sub-Acute Toxicosis Caused by Multiple Doses of Tegafur/Uracil for Suicide: A Case Report

January 2007 in “ The Kitakanto Medical Journal ”

Shuichi Hagiwara, Takashi Ogino, Yuga Takahashi, Akira Isaka, Taro Nameki, Kaie Kagoshima, Takuro Yamada, Kouichi Ishihara, Hikaru Hiraishi, Kazutaka Kurabayashi, Hiroshi Handa, Yuichi Iino

tegafur uracil UFT hair loss granulocyte colony-stimulating factor G-CSF bone marrow suppression

TLDR Effective treatment for UFT overdose includes antibiotics and G-CSF, with bone marrow biopsy and transfusion as backup options.

A 41-year-old man attempted suicide by ingesting a large dose of the oral anticancer drug tegafur/uracil (UFT), leading to sub-acute toxicosis characterized by bone-marrow suppression and hair loss. His condition was treated successfully with empiric antibiotic therapy and granulocyte colony-stimulating factor (G-CSF). The report highlighted the importance of strong antibacterial chemotherapy and G-CSF in managing UFT toxicosis, and suggested that if G-CSF is ineffective, a bone marrow biopsy and potential bone marrow transfusion should be considered.

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