TLDR A woman had severe reactions to methotrexate, including skin issues and organ problems, but improved after 38 days in the hospital.
A 30-year-old woman treated with a single dose of methotrexate (MTX) for ectopic pregnancy experienced severe multi-organ involvement, including generalized pustular rashes, alopecia, hyperpigmentation, nausea, vomiting, oral ulcers, and raised creatinine levels. She was admitted to the emergency department three days post-treatment and later transferred to the ICU due to pancytopenia, fever, and loss of consciousness. After 38 days of hospitalization, her condition improved with leucovorin and supportive care.
155 citations,
August 1991 in “Journal of The American Academy of Dermatology” Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
172 citations,
November 1983 in “Journal of The American Academy of Dermatology” Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.
4 citations,
January 2012 in “Chemical Immunology” Some drugs, especially biologics, can cause skin reactions that look like other skin diseases, and stopping the drug usually helps clear up these reactions.
November 2019 in “Harper's Textbook of Pediatric Dermatology” The document is a detailed medical reference on skin and genetic disorders.
4 citations,
January 2012 in “Elsevier eBooks” The document concludes that various skin conditions have specific treatments, ranging from antihistamines for urticaria to surgery and medication for tumors and chronic skin diseases.
25 citations,
July 2021 in “Journal of Medical Virology” COVID-19 can cause various skin issues, including rashes and hair loss, which usually heal on their own and don't always indicate severe illness.
141 citations,
September 2016 in “European Journal of Dermatology” Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.
