Hyperpigmentation, Severe Alopecia, and Six Days of Instability in a Case of Severe Methotrexate Hypersensitivity Reaction
January 2021
in “
Daru
”
TLDR A woman had severe reactions to methotrexate, including skin issues and organ problems, but improved after 38 days in the hospital.
A 30-year-old woman treated with a single dose of methotrexate (MTX) for ectopic pregnancy experienced severe multi-organ involvement, including generalized pustular rashes, alopecia, hyperpigmentation, nausea, vomiting, oral ulcers, and raised creatinine levels. She was admitted to the emergency department three days post-treatment and later transferred to the ICU due to pancytopenia, fever, and loss of consciousness. After 38 days of hospitalization, her condition improved with leucovorin and supportive care.
