118 citations
,
February 2009 in “Fertility and Sterility” This study found that approximately 75% of women with PCOS exhibited hyperandrogenemia, with free testosterone being the most frequently elevated marker.
67 citations
,
February 2010 in “Acta Obstetricia et Gynecologica Scandinavica” In this study, hirsutism in women with PCOS was strongly associated with hyperandrogenism and metabolic abnormalities, while acne and androgenic alopecia were not effective markers for hyperandrogenism.
66 citations
,
November 2001 in “European journal of endocrinology” This study suggests that decreased SHBG levels and increased FAI, free testosterone, and DHEAS concentrations are effective in diagnosing PCOS in epidemiological studies of women of reproductive age.
45 citations
,
January 2013 in “Journal of Human Reproductive Sciences” In this study, women with PCOS had a higher prevalence of hepatic steatosis compared to controls, with associated metabolic issues like insulin resistance and metabolic syndrome.
25 citations
,
December 2017 in “The Journal of Clinical Endocrinology & Metabolism” This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.
21 citations
,
September 2019 in “Archives of Physiology and Biochemistry” In this study, HIIT increased adiponectin levels and improved cholesterol profiles in women with PCOS, but did not change leptin or vaspin levels.
17 citations
,
September 2017 in “Journal of Cosmetic Dermatology” In this study of women with PCOS, hirsutism strongly correlated with metabolic abnormalities, while acne and androgenic alopecia were not clear markers of biochemical hyperandrogenemia or metabolic dysfunction.
13 citations
,
June 1989 in “Pediatric clinics of North America/The Pediatric clinics of North America” This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.
10 citations
,
May 2009 in “Cases Journal” This case study reports that a virilizing Leydig cell type ovarian tumor in a 40-year-old woman caused hyperandrogenism and virilization symptoms, which improved post-surgery.
8 citations
,
March 2010 in “Gynecological Endocrinology” This study assessed various androgens' diagnostic effectiveness for hyperandrogenaemia in PCOS using ROC curve analysis, but it reports no specific new results.
6 citations
,
June 2017 in “Reproductive Biomedicine Online” This study found that women with polycystic ovary syndrome in China had elevated androgen levels compared to healthy controls, and suggests body weight management and SHBG and FAI testing are recommended for these women.
5 citations
,
June 2010 in “Endocrinología y Nutrición” This article discusses PCOS in adolescents and highlights the importance of early diagnosis and treatment to prevent long-term health complications, noting increasing adolescent obesity may worsen symptoms.
4 citations
,
April 2017 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found a 21-fold increased risk of metabolic syndrome associated with a higher waist-hip ratio in women with polycystic ovary syndrome, highlighting the need for focused management in obese patients.
3 citations
,
August 2017 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.
2 citations
,
March 1977 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This study found that mink pelts with "singe" and "red hip" defects often exhibit split hair tips and altered cuticle structures, which may contribute to their undesired metallic sheen.
April 2024 in “Research Square (Research Square)” In this randomized trial, lupus patients taking daily 200 μg selenium supplements for eight weeks showed significant improvements in metabolic markers like CRP, ESR, MDA, and GPX, as well as reduced clinical symptoms such as arthritis and alopecia, compared to those receiving a placebo.
May 2023 in “Sučasna pedìatrìâ. Ukraïna” In a clinical observation study, researchers documented a case of total alopecia in an 11-year-old child, highlighting a potential link to genetic conditions such as autoimmune polyendocrinopathy candidiasis-ectodermal dystrophy (APECED syndrome) requiring further genetic and serological testing to verify the diagnosis.
April 2021 in “Journal of evolution of medical and dental sciences” This study found that bioavailable testosterone and the free androgen index were significantly associated with various clinical and biochemical features of PCOS, including hirsutism, showing higher levels in PCOS patients compared to controls.
September 2016 in “Springer eBooks” This review discusses how physical appearance, including skin, facial features, and physique, is linked to aging and health risks, but reports no new experimental results.
October 2021 in “Research Square (Research Square)” This study found that gene expression patterns can effectively distinguish the cashmere growth cycle stages and highlight molecular pathways, suggesting melatonin's role in regulating cashmere growth in Inner Mongolian goats.
June 2021 in “Research Square (Research Square)” This study reports that melatonin influences gene expression related to cashmere growth cycles in Inner Mongolian cashmere goats, potentially aiding in understanding and enhancing cashmere yield through molecular regulation.
December 2015 in “Revista Chilena de Dermatología” This article discusses the dermatological manifestations of polycystic ovary syndrome and emphasizes the importance of recognizing acne, hirsutism, and alopecia for early diagnosis; it reports no new clinical results.
January 2014 in “Revista del Centro Dermatológico Pascua” This study found no difference in lipid levels between men with and without androgenetic alopecia, suggesting the increased heart disease risk associated with this condition does not solely depend on cholesterol and triglyceride levels.
December 2009 in “DergiPark (Istanbul University)” This study found that low levels of ferritin and iron were common among women with diffuse hair loss, suggesting these tests could be useful in evaluating such patients.
21 citations
,
December 2016 in “PLOS ONE” This study developed a new protocol to efficiently produce skin dermal stem cells from human induced pluripotent stem cells, which may aid in treating various skin disorders.
17 citations
,
April 2010 in “Archives of Gynecology and Obstetrics” This study found that obese Taiwanese women had a lower incidence of acne than non-obese women, despite having higher serum testosterone levels.
99 citations
,
January 2014 in “Nature communications” In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.
36 citations
,
January 2018 in “Scientific reports” This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.
32 citations
,
October 2015 in “Frontiers in Cellular Neuroscience” This study found that in male rat hippocampal slices, DHT is necessary for low frequency stimulation-induced long-term depression, while E2 synthesis is essential for high frequency stimulation-induced long-term potentiation.
30 citations
,
May 2018 in “Experimental Dermatology” This article reviews the cellular dynamics affecting dermal papilla size in androgenetic alopecia and suggests targeting DP size could improve therapies, but it presents no new clinical data.