September 2022 in “Journal of Sulaimani Medical College” In this study, the combination of topical minoxidil 5% and betamethasone valerate 0.1% achieved slightly higher depigmentation in vitiligo of hair-bearing areas but did not show significant improvement over betamethasone valerate alone.
May 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review examines recent advancements in topical formulations for alopecia treatment, but it reports no new clinical results, emphasizing potential strategies to enhance drug delivery to the scalp.
March 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” In this study, eight Chinese patients with alopecia areata showed hair regrowth following combination therapy with a nonablative laser and topical minoxidil, with most patients not experiencing relapse after one year, suggesting a promising alternative treatment without significant side effects.
March 2023 in “Advances in Clinical and Experimental Medicine” This systematic review concluded that 5 mg of oral finasteride per day could be an effective and safe treatment for female pattern hair loss in normoandrogenic women, particularly when combined with other medications.
33 citations
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July 1992 in “Journal of Investigative Dermatology” Minoxidil doesn't affect perifollicular lymphoid infiltration in alopecia areata patients.
26 citations
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January 1987 in “Archives of Dermatology” In this study, topical minoxidil did not show an antiandrogenic effect on androgen-dependent cutaneous structures in the golden Syrian hamster, suggesting it likely does not have this role in humans either.
5 citations
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January 2017 in “Journal of Nanomedicine & Nanotechnology” This article discusses the formulation of nanoemulsion systems as advanced drug delivery mechanisms, but it reports no new clinical findings.
42 citations
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December 2015 in “International Journal of Clinical Pharmacology and Therapeutics” This study found that applying a novel 0.25% finasteride solution to the scalp can effectively reduce scalp DHT levels in men with androgenetic alopecia, potentially reducing systemic side-effects.
34 citations
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October 2014 in “European journal of pharmaceutics and biopharmaceutics” This study found that adapalene-loaded solid lipid microparticles may enhance targeted drug delivery into sebum due to their similarity to sebum components, although both this formulation and a standard cream showed equivalent follicular penetration.
10 citations
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December 2020 in “Dermatologic Therapy” This study found that topical minoxidil 5% gel and spironolactone 1% gel were both effective treatments for androgenetic alopecia, with a combination of both providing the best clinical response and achieving 100% effectiveness among participants.
5 citations
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September 2015 in “Medical hypotheses” This article suggests that a topical sulfonylurea drug may inhibit excessive hair growth caused by diazoxide without affecting its beneficial effects on beta cells, potentially offering a treatment for various forms of hypertrichosis and hirsutism.
1 citations
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January 2024 in “Journal of Feline Medicine and Surgery Open Reports” In this study, the researchers describe a case of feline demodicosis that presented with dermatological lesions but lacked the typical signs of pruritus or overgrooming, and they report successful off-label treatment using a single spot-on application of fluralaner.
1 citations
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April 2017 in “Journal of Investigative Dermatology” This study found that a novel 15% topical minoxidil solution achieved a clinically significant hair regrowth response in 60% of women with female pattern hair loss who did not respond to 5% minoxidil, without increasing adverse events.
August 2023 in “Medical Hypotheses” In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.
November 2017 in “Dermatologic Therapy” This study reports that a new topical solution, AB-102, containing a high concentration of a weak α1 agonist, significantly reduces hair shedding during brushing by up to 77% without causing cardiac or hemodynamic adverse events.
January 2026 in “Dermatologic Therapy” This study found that a novel topical dutasteride lotion, FOL100, demonstrated excellent safety, tolerability, and usability with promising signs of clinical benefit for mild-to-moderate male pattern baldness.
March 2025 in “Drug Development Research” In this study, researchers developed a novel topical gel combining minoxidil and JAK inhibitor tofacitinib, which effectively enhanced hair follicle growth and reduced local inflammation in mice with alopecia areata, suggesting a new approach for treating this condition.
This proof-of-concept study suggests that the new topical treatment regimen TH07 may offer effective hair growth results in men with androgenic alopecia, using a combination of finasteride, latanoprost, and minoxidil, supported by animal models and clinical studies.
February 2022 in “Institutional Repositories DataBase (IRDB)” This case study describes a unique instance of unilateral steroid-induced rosacea-like dermatitis likely due to long-term localized use of topical corticosteroids, emphasizing the need for careful application and thorough histopathological analysis.
January 2022 in “Yonago Acta Medica” This case report describes a Japanese woman with unilateral steroid-induced rosacea-like dermatitis attributed to long-term topical corticosteroid use, highlighting the significance of appropriate steroid application and histopathological evaluation for facial erythematous nodules.
22 citations
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August 2013 in “PLOS ONE” This study found that using a non-invasive multielectrode array for gene electrotransfer in hairless guinea pigs increased gene expression in the epidermis significantly, with minimal skin changes observed.
21 citations
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January 2017 in “Skin Pharmacology and Physiology” In this noninferiority study, researchers found that a 0.2% caffeine-based topical liquid was not less effective than 5% minoxidil solution in improving hair growth in men with androgenetic alopecia over six months.
April 2020 in “Dermatology and therapy” In this study, the novel 5% minoxidil formulation significantly increased scalp hydration and decreased redness in Indian men with androgenetic alopecia compared to alcohol-based formulations.
61 citations
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May 2016 in “Scientific reports” This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.
27 citations
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September 2017 in “Archives of Dermatological Research” In this study, topical tofacitinib significantly increased hair regrowth in mice compared to minoxidil or vehicle, potentially due to elevated VEGF levels and reduced inflammation.
11 citations
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April 1997 in “International Journal of Dermatology” This article discusses using topical tretinoin with intralesional triamcinolone acetonide for alopecia areata in northern Saudi Arabia, but it reports no new clinical findings.
4 citations
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August 2014 in “Dermatology and Therapy” This study suggests that LOYON® is safe, well tolerated, and effective in reducing scaling from cradle cap in infants and children without causing spot bleedings.
4 citations
,
June 2013 in “Aesthetic Plastic Surgery” This study found that minoxidil pretreatment in rat skin flaps enhanced angiogenesis and increased flap survival compared to untreated flaps, but was less effective at reducing necrosis than surgical delay.
1 citations
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January 2025 in “Journal of Clinical and Investigative Dermatology” This study observed significant improvements in hair loss and hair density among adults using USPlus DERM Topical serum daily for 12 weeks, with 90.9% of participants noticing better hair loss/density and rating satisfaction at an average of 7.7 out of 10.
April 2018 in “Journal of Investigative Dermatology” In this study, topical tofacitinib significantly promoted hair regrowth in mice, outpacing both minoxidil and controls over 21 days, with findings suggesting increased VEGF levels and decreased inflammation as possible mechanisms.