7 citations
,
January 2021 in “The journal of gene medicine” Certain genetic differences may affect how likely someone is to get COVID-19 and how severe it might be.
6 citations
,
January 2024 in “Cancers” This systematic review found that antiandrogens do not appear to protect against SARS-CoV-2 infection or reduce COVID-19 severity, suggesting their use is not advisable for COVID-19 treatment.
3 citations
,
April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study presents a new method using primary human lung tissue cells to rapidly identify viral entry factors and therapeutics for SARS-CoV-2, revealing compounds overlooked by conventional screening systems.
1 citations
,
January 2022 in “PLoS Pathogens” In this study, researchers developed a rapid platform using primary human lung tissues to identify SARS-CoV-2 targets and test antiviral compounds, achieving highly reproducible results across viral variants.
1 citations
,
August 2021 in “Internal Medicine Journal” This article is a letter to the editor discussing late unexpected consequences of COVID-19 infection in individuals who survived acute hypoxic respiratory failure and includes no new research results.
185 citations
,
August 2020 in “Mayo Clinic Proceedings” This review discusses biological sex differences in COVID-19 outcomes and reports no new clinical results; it identifies a need for studies to clarify how sex influences disease progression.
134 citations
,
April 2020 in “Journal of Cosmetic Dermatology” Male pattern hair loss could hint at androgens affecting COVID-19 severity.
113 citations
,
July 2020 in “Communications biology” This review suggests that understanding the biological and molecular reasons for more severe COVID-19 in men, particularly those at risk for prostate cancer, could improve management of these patients, but reports no new results.
60 citations
,
January 2023 in “Biogerontology” This review examines testosterone's role in male health and aging but reports no new clinical results; the authors highlight the need for further research on optimal testosterone levels to prevent age-related conditions.
49 citations
,
January 2021 in “Journal of The European Academy of Dermatology and Venereology” Anti-androgens, like finasteride, dutasteride, and spironolactone, may lessen the severity of COVID-19 in men, leading to fewer ICU admissions.
47 citations
,
April 2020 in “Dermatologic Therapy” This letter discusses the potential connection between androgenetic alopecia and COVID-19, suggesting a possible new therapy, but it reports no new results.
36 citations
,
November 2020 in “Journal of The European Academy of Dermatology and Venereology” This study found that 5-alpha-reductase inhibitors were associated with a reduced frequency of COVID-19 symptoms in males with androgenetic alopecia.
32 citations
,
July 2020 in “Journal of The American Academy of Dermatology” This study noted that among hospitalized COVID-19 patients, androgenetic alopecia was prevalent, and severe cases were associated with adverse outcomes such as respiratory failure, highlighting a possible link with androgen sensitivity.
27 citations
,
October 2020 in “Experimental Dermatology” This study found that both extensive grey hair and alopecia were independently associated with increased COVID-19 severity among survey respondents in Brazil.
26 citations
,
September 2020 in “Journal of the European Academy of Dermatology and Venereology” This publication is a letter discussing the association between an androgen receptor genetic variant and COVID-19 disease severity in hospitalized male patients, but it reports no new research results.
24 citations
,
February 2022 in “Reviews in Endocrine and Metabolic Disorders” This review reports that women with polycystic ovary syndrome are at 28%–50% higher risk of SARS-CoV-2 infection, with increased rates of COVID-19-related hospitalization, morbidity, and mortality.
21 citations
,
May 2021 in “Prostate Cancer and Prostatic Diseases” This review analyzes the potential mechanisms by which SARS-CoV-2 may exacerbate symptoms of benign prostatic hyperplasia and suggests a connection via ACE2 and androgen receptor pathways; it reports no new clinical results.
15 citations
,
August 2021 in “Reviews in endocrine and metabolic disorders” This review discusses hypopituitarism's bidirectional relationship with COVID-19 due to metabolic comorbidities and pituitary risks, but it reports no new clinical results.
8 citations
,
May 2022 in “Journal of medicine and life” This study found that telogen effluvium, a type of hair loss, was prevalent among 24% of COVID-19 patients, likely triggered by stress and medication related to the illness.
6 citations
,
December 2020 in “Dermatological reviews” This review discusses the potential link between androgenic alopecia, androgens, and the severity of COVID-19, highlighting possible therapeutic targets but reports no new clinical results.
5 citations
,
July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that a 14-day treatment with proxalutamide significantly reduced the 28-day mortality rate in hospitalized COVID-19 patients compared to placebo, with greater benefits observed among those who adhered to the treatment.
5 citations
,
May 2020 in “Dermatologic Therapy” This letter reports no new findings and discusses potential concerns regarding 5-alpha reductase inhibitors on lung function, suggesting a reason for discontinuation during the COVID-19 pandemic.
4 citations
,
May 2021 in “Journal of The European Academy of Dermatology and Venereology” This study found no significant correlation between androgenetic alopecia or other hyper-androgenic skin manifestations and the severity of COVID-19 outcomes in hospitalized patients.
3 citations
,
December 2021 in “Physiological Research” This review discusses the potential link between androgen deficiency and increased COVID-19 severity in aging men, but reports no new clinical results; it suggests that low testosterone levels may pose a risk factor.
1 citations
,
April 2021 in “International Journal of Dermatology” This review discusses the relationship between hyperandrogenic conditions like PCOS and COVID-19, noting that while hyperandrogenic women have varied hospitalization rates, they do not show increased mortality, and suggests isotretinoin as a potential therapeutic option for cutaneous symptoms.
1 citations
,
March 2021 in “The Journal of Sexual Medicine” This study reported that testosterone replacement therapy was not linked to worse COVID-19 outcomes in men, though the data showed high hospitalization and fatality rates that suggest otherwise.
April 2026 in “Signal Transduction and Targeted Therapy” In a hamster model of COVID-19, this study observed that both low and high doses of testosterone worsened illness in males, while finasteride prevented severe outcomes.
December 2022 in “Urology Herald” This review examines existing research on androgen deprivation therapy and its effects on male sex hormones in relation to COVID-19, but reports no new clinical findings.
June 2021 in “EBioMedicine” This paper reports no new results; it addresses the effects of Dutasteride on testosterone and DHT in men, and discusses the implications for androgen deprivation and COVID-19 outcomes.
January 2021 in “Journal of the European Academy of Dermatology and Venereology” PrEP doesn't increase STI risk in high-risk men, anti-androgen drugs may lower ICU admission for male COVID-19 patients, a 3-point injection is better for crow's feet, and the 'Geriatric-8' tool could help assess frailty in older skin cancer patients.