65 citations
,
August 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Anti-acne medications may work by reducing the activity of a protein involved in acne development.
55 citations
,
May 2010 in “Cancer and Metastasis Reviews” TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
4 citations
,
January 2017 in “Development” Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.
June 2024 in “International journal of molecular sciences” Adenosine complex helps increase hair thickness and density in hair loss.
October 2023 in “Current Issues in Molecular Biology” The YH complex, made from Astragalus membranaceus and Cinnamomum cassia, may help treat hair loss by promoting hair growth and follicle development.
300 citations
,
October 2012 in “Seminars in Cell & Developmental Biology” The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
25 citations
,
May 2017 in “Experimental Dermatology” The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.
18 citations
,
February 2018 in “International Journal of Molecular Sciences” PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
18 citations
,
July 2014 in “Stem cells” The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.
417 citations
,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
64 citations
,
March 2017 in “Nature communications” Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
64 citations
,
April 2005 in “Journal of Investigative Dermatology” Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.
49 citations
,
January 2010 in “Journal of Investigative Dermatology” Thyroid function affects skin health, with a complex interaction between the two.
48 citations
,
March 2019 in “Frontiers in Physiology” Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.
40 citations
,
March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
39 citations
,
April 2015 in “Regeneration” Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.
28 citations
,
October 2008 in “Developmental Biology” Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.
25 citations
,
January 2020 in “Genomics” Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.
25 citations
,
August 2019 in “Experimental Dermatology” Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.
21 citations
,
March 2020 in “Cardiovascular Research” High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.
21 citations
,
April 2019 in “Experimental Dermatology” Immune cells around hair follicles help control hair growth and could be targets for treating hair disorders.
20 citations
,
September 2010 in “Cell Cycle” Mice can regenerate ear tissue without the p53 protein.
19 citations
,
April 2015 in “International Journal of Molecular Sciences” The research identified genes and pathways important for sheep wool growth and shedding.
18 citations
,
December 2020 in “Frontiers in cell and developmental biology” miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.
4 citations
,
November 2022 in “Frontiers in endocrinology” The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
4 citations
,
November 2017 in “Scientific Reports” The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.
3 citations
,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.
3 citations
,
May 2010 in “Endocrinology” The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.
2 citations
,
August 2020 in “Scientific reports” Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.
July 2023 in “The Egyptian Journal of Hospital Medicine ” Alopecia areata is a hair loss condition caused by immune factors and can be treated with JAK inhibitors.