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240-270 / 1000+ resultsresearch Safety and efficacy of advanced and targeted acid α-glucosidase (AT-GAA) (ATB200/AT2221) in ERT-switch nonambulatory patients with Pompe disease: preliminary results from the ATB200-02 trial
This study found that coadministration of tadalafil and finasteride improved lower urinary tract symptoms and erectile function in men with benign prostatic hyperplasia better than finasteride alone over 26 weeks.
research Skin Gamma Delta T Cell Gene Expression Highlights Stress Response in Alopecia Areata 2258104
This study observed that in both mouse and human models of alopecia areata, T cells exhibit a stress response involving heat shock proteins and other regulatory markers, suggesting their potential as targets for therapeutic intervention in this autoimmune skin disease.
research Temporal triangular alopecia: significance of trichoscopy in differential diagnosis
This study suggests that trichoscopy with a handheld dermatoscope may help differentiate temporal triangular alopecia from other localized alopecia by identifying specific hair features.
research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.
research THE FREQUENCY OF VISCERAL AND PHENOTYPIC MARKERS IN PATIENTS WITH THE COMBINATION OF UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE AND GASTROESOPHAGEAL REFLUX DISEASE
This study found that patients with GERD and UCTD have significantly more frequent phenotypic and visceral markers than those with GERD alone, which should inform early diagnostic and treatment strategies.
research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation
In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.
research Dependence of anxiolytic effects of the dipeptide TSPO ligand GD-23 on neurosteroid biosynthesis
This study found that GD-23, a dipeptide ligand of TSPO, exhibited an anxiolytic effect in the elevated plus maze test, which was inhibited by selective neurosteroid synthesis inhibitors, suggesting a neurosteroidogenic mechanism.
research Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.
This case study reports successful treatment of an 11-year-old girl's trichotillomania with cognitive behavioral therapy, mild topical treatments, and supportive parental involvement, without psychopharmacologic intervention.
research 42017 Androgenetic Alopecia Incidence in Transgender and Gender Diverse Patients on Hormone Therapy Compared to Cisgender Patients
This article discusses the incidence of androgenetic alopecia in transgender and gender diverse patients undergoing gender affirming hormone therapy but presents no new clinical findings, highlighting a gap in large-scale studies.
research Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment.
In this study, early prenatal treatment with Minoxidil, a lysyl hydroxylase inhibitor, partly improved cardiac outflow tract septation in Tbx1 mutant mice, suggesting that inhibiting collagen cross-linking may mitigate some effects of Tbx1 mutation associated with DiGeorge syndrome.
research Successful Management of Trichotillomania with an Integrated Approach: A Case Study
In this case study, a 22-year-old female with trichotillomania showed significant improvement through an integrated approach combining Growth Factor Concentrate therapy, Ayurvedic medications, counseling, and yogic practices, highlighting the importance of addressing both dermatological and psychological aspects for long-term recovery.
research Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor
This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.
research Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice
This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.
research Direct-to-Consumer Teledermatology for Male Androgenetic Alopecia: Narrative Review
This narrative review reported that direct-to-consumer teledermatology improves access to care, adherence, and patient satisfaction for treating male androgenetic alopecia, but may lead to higher drug costs.
research Innovation and Kindness for Hair: Tangle Teezer launches Extra Gentle – The Brush that Supports Hair Health with Science and Softness
This report from Tangle Teezer and TRI Princeton indicates that their Extra Gentle brush reduces hair breakage by up to 39%, offering a therapeutic experience for users with fragile scalps.
research Inducible, reversible hair loss in transgenic mice.
This study suggests that inducible transgenic mice showing hair follicle changes similar to telogen effluvium in humans might serve as a useful model for understanding this type of hair loss.
research Biotinidase deficiency characterized by skin and hair findings
This case report describes a girl in China with biotinidase deficiency confirmed by genetic mutations, whose skin and hair symptoms improved with biotin therapy.
research Reprofiling synthetic glucocorticoid-induced leucine zipper fusion peptide as a novel and effective hair growth promoter
TAT-GILZ peptide promotes hair growth by boosting stem cell activity.
research Small cell lung cancer: Results of a phase II study of 1,2,4 triglycidylurazol
The drug TGU was ineffective against small cell lung cancer and caused significant bone marrow suppression.
research TGF-α Is Widely Expressed in Differentiated as well as Hyperproliferative Skin Epithelium
research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44
This study found that PGD2 inhibits hair follicle regeneration in mice through the Gpr44 receptor, suggesting that blocking PGD2 or Gpr44 may enhance skin regeneration after wounds.
research 001 Human scalp hair follicles are protected from alopecia areata in vivo by regulatory γδT cells
γδT cells can protect hair follicles from alopecia areata and promote hair regrowth.
research Ichthyosis and Trichothiodystrophy: the Tay and PIBI(D)S Syndromes
This article discusses the history and understanding of Tay syndrome, recognizing it as a distinct condition related to ichthyotic erythroderma, mental retardation, and brittle hair but reports no new clinical results.
research Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata
This study found that total glucosides of paeony (TGP) reduced hair loss and inflammation in alopecia areata mice by inhibiting cellular pyroptosis.
research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia
TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
research Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium
This study identified genetic variations in the DSG4 gene among sheep, revealing valuable markers for assessing their impact on wool traits.
research Contrast enhanced phototrichogram (CE-PTG): an improved non-invasive technique for measurement of scalp hair dynamics in androgenetic alopecia–validation study with histology after transverse sectioning of scalp biopsies.
This study found that contrast enhanced phototrichogram (CE-PTG) significantly improved detection of various hair types and growth stages in androgenetic alopecia compared to standard PTG and was comparable to biopsy analysis.
research Research Highlights: γδ T cells regulate hair follicle neogenesis during adult wound healing
This summary reports that γδ T cells play a role in regulating hair follicle formation during wound healing in adult skin.
research Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.
This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.