Six SNPs and a TTG Indel in Sheep Desmoglein 4 Gene Are in Complete Linkage Disequilibrium

July 2011 in “ AFRICAN JOURNAL OF BIOTECHNOLOGY ”

Ge Zhang, Yue-Hui Ma, Yuanyue Zhang, Weijun Guan, Qianjun Zhao, Hui-jing Zhao, Jianlin Han

desmoglein 4 DSG4 hair follicle regulation polymorphisms linkage disequilibrium haplotypes SNPs indel amino acid changes genetic markers

TLDR Seven genetic variations in sheep's DSG4 gene are linked and affect wool traits.

This study investigated the desmoglein 4 (DSG4) gene in 544 sheep from various breeds, focusing on its role in hair follicle regulation. Researchers identified polymorphisms in two gene fragments, which were in strong linkage disequilibrium, resulting in three haplotypes: AD, BE, and CD. Haplotype AD was predominant across all breeds, while BE was unique to Chinese breeds with varying frequencies, and CD was extremely rare. The study found seven SNPs and a TTG indel, causing five amino acid changes and a glycine indel. These findings provided genetic markers useful for assessing DSG4's impact on wool traits in sheep.

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