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This review examines the scientific evidence on the short-term safety of testosterone therapy for treating hypoactive sexual desire disorder in women, without presenting new clinical results.

In this case study, authors reported that a 43-year-old female patient initially showed persistently high testosterone levels due to immunoassay interference, later verified as normal using liquid chromatography-tandem mass spectrometry (LC-MS/MS), highlighting the need to consider assay artifacts in diagnosing hyperandrogenism without clinical signs.

In this retrospective study, among transfeminine patients aged 19-81 receiving gender-affirming estrogen therapy, 100% achieved testosterone suppression without anti-androgens when serum estradiol exceeded 100pg/mL, predominantly using injectable estrogen.

This case report describes a 22-year-old woman with hirsutism and irregular menstrual bleeding, diagnosed with an ovarian steroid cell tumor (NOS), whose androgen levels normalized after surgery.

This review summarizes the latest evidence on testosterone, detailing its clinical indications, diagnostic tests, and impacts on various male organs, while also noting its association with aging, metabolic disorders, and increased mortality risk due to androgen deficiency.

This study reported that testosterone replacement therapy was not linked to worse COVID-19 outcomes in men, though the data showed high hospitalization and fatality rates that suggest otherwise.

This study found that 5 alpha-dihydrotestosterone increased pigmentation in dorsal spots and scrotal skin of prepubertal male Syrian hamsters, while estradiol decreased scrotal skin melanocytes and reversed androgen-induced pigmentation in costovertebral spots.

This case study found that in a male-to-female transgender individual, long-term cyproterone use led to decreased bone mass, which improved with additional oestradiol treatment, highlighting the anabolic role of oestrogens on bone health.

This review highlights the mixed roles of testosterone in COVID-19, noting both potential benefits through anti-inflammatory effects and risks due to increased virus entry, with low testosterone linked to increased severity.

Testosterone may both worsen and protect against COVID-19 effects in men.

This study suggests that testosterone therapy in AFAB individuals may modify the methylation of the ESR2 promoter, with changes influenced by factors like total testosterone levels and age.

This study found that elevated free testosterone levels may reduce body fat and increase bone density in males, but also raise the risk of prostate cancer, hair loss, and benign prostate hyperplasia.

This study found that while testosterone administration reduced myocardial damage in gonadectomized rats after ischemia/reperfusion injury, Finasteride led to greater improvements, whereas 4-hydroxyandrostenedione worsened outcomes.

This study indicates that the normal human prostate is not a major contributor to circulating blood DHT concentrations in androgen-deficient patients receiving testosterone replacement therapy.

In this case study, a 69-year-old woman with signs of virilization and high testosterone levels was found to have an ovarian steroid cell tumor, highlighting the importance of systematically investigating such symptoms in postmenopausal women to determine the underlying etiology and prevent poor prognosis.

This article reviews the clinical and biochemical features of genetic mutations affecting dihydrotestosterone production and their potential role in male pseudo-hermaphroditism, but presents no new clinical results.

This case report describes three instances where occult ovarian Leydig cell tumors were suspected based on severe hyperandrogenism symptoms, despite negative imaging findings, highlighting that elevated testosterone levels are a crucial diagnostic marker.

This case report describes a 65-year-old postmenopausal woman with hyperandrogenism caused by a non-malignant ovarian Leydig cell tumor, which is a rare cause of virilization.

This article discusses testosterone production in the human body and its effects on muscle mass, bone density, metabolism, and skin, but reports no new findings.

This study found that testosterone therapy can enhance sexual satisfaction and mood in surgically menopausal women on oestrogen, though ongoing monitoring and research are needed to assess long-term safety and effects in other groups.

This study describes a method to estimate endogenous hormone production by neutralizing an endogenous hormone with an oppositely acting hormone.

This case study reports that hormonal imbalances in a young boy with precocious pseudopuberty returned to normal after the removal of a testicular interstitial cell tumor, with normal spontaneous puberty following.

This review discusses a new multidisciplinary guideline for treating male hypogonadism and emphasizes a comprehensive approach but reports no new experimental results.

This article discusses the considerations and challenges surrounding a proposed large-scale trial on testosterone-replacement therapy in older men and reports no new results.

This review concluded that for women, the benefits of testosterone implants are outweighed by risks, with possible higher rates of irreversible adverse effects than previously reported.

This case study reports that a 16-year-old girl with hirsutism and menstrual irregularities was diagnosed with a benign steroid cell ovarian tumor, after high testosterone levels indicated a potential androgen-secreting source.

This document outlines recommendations from an international panel on testosterone therapy for aging men with late-onset hypogonadism, emphasizing the need for careful assessment and monitoring due to limited long-term safety data.

This study observed that "physiological" hyperandrogenism due to elevated total testosterone was associated with a 23.5% incidence of arterial hypertension, unlike hyperandrogenism due to elevated DHT levels.

This case study reported a 68-year-old woman with postmenopausal virilization due to a rare Sertoli-Leydig cell tumor, where her symptoms and elevated testosterone levels only normalized post-surgery, underscoring the importance of thorough evaluation in such cases to improve diagnosis and treatment.

This study found that epitestosterone, a stereoisomer of testosterone, is metabolized to 5α-dihydroepitestosterone by human 5α-reductase enzymes, which enhances its androgenic activity and reduces its antagonistic effect on testosterone-driven androgen receptor signaling.