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In this study, females with PCOS experienced greater depressive symptoms and cognitive impairment linked to high testosterone levels, but anti-androgen treatment significantly improved mood and cognitive function.

This article reports two cases where ovarian hyperthecosis caused hyperandrogenism in postmenopausal women, confirmed by imaging and resolved after bilateral oophorectomy.

In this study, the ethanol extract of Zapoteca portoricensis stem significantly reduced markers of testosterone-induced benign prostate hyperplasia in male albino rats without harming liver and kidney function.

In this study, PGD2 treatment in keratinocytes increased testosterone production via reactive oxygen species, suggesting a potential role for the NRF2 pathway in androgenic alopecia treatment strategies.

This study found that biochanin A promoted hair growth in testosterone-induced alopecia mice, possibly by inhibiting 5α-reductase activity and altering testosterone activity.

In this study, the medicated oil made from Martynia annua leaves showed strong hair growth-promoting activity in a mouse model of testosterone-induced alopecia, potentially outperforming the standard treatment, finasteride.

This study found that testosterone, finasteride, and castration in rats decreased serum thyroxin levels, with testosterone also affecting body and prostate weights.

This study suggests that greater sensitivity to androgens, as indicated by higher than grade 2 androgenic alopecia, may reduce the risk of schizophrenia by 8.62 times.

Testosterone therapy may help men with osteoporosis.

This study found that androgenic hormone levels did not explain growth differences between furless and furred male rabbits, despite a potential growth advantage in furless rabbits.

In this systematic review, researchers observed that Toxoplasma gondii infection is associated with alterations in testosterone levels, generally increasing in humans but showing mixed effects in animals, highlighting a complex relationship that warrants further investigation.

This study found that administering an alcoholic extract of Mentha spicata leaves significantly reduced testosterone levels and aggressive behavior in female rats with elevated testosterone, suggesting its potential protective role against such symptoms.

This study observed that testosterone concentrations in hair segments show some stability over time, but are influenced by factors like sebum integration, hair washing frequency, and individual hair growth rates.

This case study highlights the complexity of managing PCOS and its symptoms in transmen, suggesting hormonal fluctuations may lead to symptomatic relief with low dose estradiol.

In this case report, the researchers emphasize the importance of regular prostate exams and PSA tests for diabetic men, including those who are hypogonadal, because prostate cancer development is linked to intraprostatic dihydrotestosterone levels, not serum testosterone levels.

This study demonstrated that cortisol, estradiol, and testosterone are preserved in archaeological human hair, allowing for the analysis of ancient stress and reproductive hormone patterns.

The researchers reported that using Natesto® testosterone gel improved erectile function and mood in hypogonadal men over a 90-day period.

This article discusses testosterone production in the human body and its effects on muscle mass, bone density, metabolism, and skin, but reports no new findings.

This study found that combining D-004 with finasteride results in more significant prevention of testosterone-induced prostate enlargement in rats compared to using either treatment alone.

In this study, researchers developed and optimized a smartlipid nanocarrier gel formulation of berberine that significantly reduced hair loss and promoted faster hair regrowth in a testosterone-induced hair loss model, showing potential as an effective treatment for androgenetic alopecia.

In this study, Quercetin-loaded black seed oil nanoemulsion effectively mitigated testosterone-induced testicular oxidative stress and inflammation in rats undergoing exercise and restraint stress, with improved antioxidant levels and reduced inflammatory markers compared to other treatment groups.

This study found that systemic testosterone exposure in transgender individuals with XX genotype alters skin biology, increasing androgen and estrogen receptor-positive cells, collagen density, and fibronectin expression while reducing immune cells, which could affect surgical outcomes by promoting a male skin phenotype.

This study found that applying an ethanol extract of Prasiola japonica improved hair regrowth, length, and follicular density in testosterone-induced hair loss conditions in mice, while also promoting dermal papilla cell proliferation and reducing dihydrotestosterone production, though effects were less pronounced than those of minoxidil.

This study found that periodic intratesticular PRP administration may slightly enhance testicular development in male lambs, indicated by increased testicular blood flow, length, and reduced resistance index compared to saline.

In this study, sublingual minoxidil was found to be a safe and effective treatment for increasing hair growth in transgender individuals with mild androgenetic alopecia who are undergoing full-dose testosterone therapy.

This study found that ethanol extract of Syzygium aromaticum (clove) leaves significantly improved lipid profiles and increased body weight in testosterone-induced benign prostatic hyperplasia rats, suggesting potential anti-hyperlipidemic effects and modulation of body weight through metabolic activity.

This case study describes a 34-year-old male developing painful inflammatory scalp nodules post-scalp microinfusion of medication. The findings suggest that repeated microtrauma or bacterial colonization might trigger dissecting cellulitis in susceptible individuals, with exogenous testosterone as a potential modifier, not a direct cause.

This narrative review concludes that long-term randomized controlled trials are needed to establish clear guidelines for testosterone therapy in women, given the lack of FDA-approved formulations and the variable quality of current treatments.

This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.