A Preliminary Study on the Effect of Biochanin A on Hair Growth in Testosterone-Induced Alopecia Mice
January 2014
TLDR Biochanin A promotes hair growth in mice with testosterone-induced hair loss.
The study investigated the effects of biochanin A on hair growth in testosterone-induced alopecia mice. Four groups were tested: blank control, alopecia model, biochanin A, and minoxidil. Significant differences in hair length, weight, follicle number, and androgen levels were observed between the alopecia model and both the blank control and biochanin A groups. Biochanin A also showed positive 5α-reductase inhibitory activity with an IC50 of 94.45 ± 6.92 μmol/L. The findings suggested that biochanin A promoted hair growth, potentially by inhibiting 5α-reductase or converting testosterone into less active products.
