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Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

New treatments for male hypogonadism are effective and should be personalized.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.

The research concluded that selection significantly shaped the genetic variation of the X chromosome, with certain regions affected by past selective events.

Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.

Post-finasteride Syndrome causes lasting negative effects, but more research is needed for treatment and risk evaluation.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Men with urinary symptoms are more likely to have erectile dysfunction, and there's a debate about research methods and authorship ethics.

Hormone treatment caused hair loss, finasteride helped regrowth.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

A new gene, JMJD1C, may affect testosterone levels in men.

Applying a specific inhibitor lightens skin and hair color.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Women with polycystic ovary syndrome tend to have a longer distance between the clitoris and anus.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

The normal human prostate does not significantly affect blood DHT levels.

These drugs cause hair growth without affecting testosterone or adrenal hormones.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.