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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Targeted cancer therapies often cause serious skin problems that need careful management.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Special fiber materials boost the healing properties of certain stem cells.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Myrtle has various health benefits and potential for medicine development.

Zinc is effective for treating various skin conditions, including warts and acne.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.