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This study found that hyperproliferative stimuli dysregulated the balance of stem cell divisions in keratinocytes, suggesting potential treatment strategies for both benign and cancerous hyperproliferative diseases.

This study found that Wnt signaling regulates the symmetric division of adult neural stem cells, increasing their numbers during subependymal regeneration, stroke response, and colony formation.

This research found that the microtubule catastrophe factor KIF18B plays a crucial role in promoting spindle orientation in keratinocytes, linking this process to cell fate decisions during hair follicle morphogenesis.

One type of progenitor cell can maintain normal skin in mice.

This research reexamined transcriptomic data to study stem and progenitor cell proliferation in psoriasis, finding that the number of committed progenitor cells increased eight-fold in psoriatic skin without altering stem cell numbers, potentially identifying new therapeutic targets.

This review evaluates methods to study stem cell division patterns, particularly in the mammary gland, and discusses genetic factors affecting division modalities and their implications for breast cancer, but reports no new results.

This review discusses the mechanisms governing epidermal stem and progenitor cell differentiation, emphasizing the balance necessary for maintaining skin barrier function, and reports no new experimental findings.

This study found that mouse hair follicle stem cells use symmetric cell division for maintenance and fate determination, and identified Gata6 as a crucial factor for their differentiation.

This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.

In this study, the authors concluded that the TS-associated polyomavirus may disrupt Wnt/β-catenin signaling, likely contributing to abnormal hair follicle formation in trichodysplasia spinulosa.

Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.

Glycogen helps E. coli cells divide unevenly and organize their contents.

This dissertation reports that horizontal basal cells in the olfactory epithelium undergo symmetric divisions balanced by population asymmetry, which supports their renewal and differentiation during tissue homeostasis and regeneration.

This study reports that fly blood progenitors in a long-term organ culture model undergo symmetric cell divisions influenced by cell size and orientation, with infection triggering changes in cell differentiation kinetics.

This study found that altering CDK4 expression in mice affects the population of keratinocyte stem cells, suggesting a correlation with susceptibility to skin papillomas.

This study discovered a novel mechanism by which germ stem cells exit their niche in C. elegans, involving thin membranous protrusions from adjacent somatic gonad cells.

This study found that DNA strand segregation in multipotent hair follicle stem cells occurs randomly during development and tissue homeostasis, challenging the immortal strand hypothesis.

This study suggests that mouse lineage specification during pre-implantation development involves distinct timing and mechanisms for trophectoderm and inner cell mass differentiation, challenging existing models.

The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.

This review discusses how stem and progenitor cells communicate to synchronize their differentiation responses, highlighting the challenges in identifying these mechanisms and surveying new technologies that may overcome these obstacles.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.

This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.

This review discusses the role of polarity signaling in coordinating tissue mechanics, micro-environmental functions, and cell fate decisions, but it reports no new results, highlighting the need for further study in mammalian models.

This study found that centrosome ablation in developing epidermis triggers cell surveillance pathways, resulting in thinner skin and halted hair follicle growth, while later stages of epidermal growth may operate independently of basal progenitor division orientation.

In this study, researchers observed that after mesenchymal cell division in mouse and chicken embryonic skin, elevated migration speed and persistence for 180 minutes contribute to mesenchymal dispersal and preferential recruitment to dermal condensates.

This study found that mutations in phosphorylation sites on the PIN3 protein disrupt its phosphorylation and subcellular trafficking, affecting auxin transport and root growth in a cell-type-specific manner.

This study found that mammary resident macrophages regulate mammary epithelium cell division and development, with implications for maintaining mammary stem cell activity and homeostasis.

In this study, 3D planned resection and reconstruction for skull defects after resection of cSCC with bony invasion led to accurate procedures, though patient-specific factors should guide treatment decisions.