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Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Blocking β-catenin in skin cells improves hair growth during wound healing.

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Human hair follicles can regenerate after removal, but with low success rate.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Stress can worsen skin conditions by affecting hormone levels and immune response.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.

Pregnant women often experience skin and hair changes, with over half getting stretch marks and pigment changes, and should be cautious with cosmetic procedures due to potential risks.

Finasteride may cause sexual side effects like erectile dysfunction, but they are reversible and affect less than 2% of men.

Losing eyelashes or eyebrows can be a sign of many different health problems and needs a careful approach to treat effectively.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.

Different hair growth problems are caused by genetic issues or changes in hair growth cycles, and new treatments are being developed.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Laser treatments are the most effective for porokeratotic adnexal ostial nevus.