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Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Baricitinib and its combination with lonafarnib improve fat cell formation in certain genetic disorders.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Fat transplants using a patient's own fat can rejuvenate and repair tissues effectively.

Metreleptin treatment significantly improved metabolic health in a boy with congenital generalized lipodystrophy.

Effective PCOS treatments require targeting specific signaling pathways.

Facelift surgery has evolved to focus on natural results and safety, with patient selection and postoperative care being key to success.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.

Patients with androgenetic alopecia have thinner subcutaneous fat layers in their frontal scalp compared to healthy individuals.

MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.

Scalp biopsy helps tell apart permanent and temporary hair loss types and guides treatment.

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

Mitochondrial therapy and platelet-rich plasma therapy both stimulated hair regrowth in aging mice, with mitochondrial therapy showing similar effectiveness to plasma therapy.

Melatonin treatment helps improve skin health in postmenopausal rats.

Taiwan reported its first case of a rare scalp condition with no clear cause or treatment.

Piperine from black pepper can make hair less oily by blocking fat cell development in hair roots.

Men and women need different facial rejuvenation treatments due to distinct aging processes and anatomical differences.

Lipedema is a painful fat disorder in women that's hard to treat, often worsens with hormonal changes, and requires symptom-focused therapies.

The document recommends a multidisciplinary approach and experience sharing to advance facial feminization surgery as a medical field.

Two sisters with lipoedematous scalp suggest a genetic influence in the condition.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

The new rodent model successfully mimics non-lean human PCOS symptoms.

Subcutaneous contraceptives can cause side effects like menstrual changes, headaches, weight gain, and pain at the implant site.

Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.