87 citations
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August 2017 in “Differentiation” This review discusses the role of stromal cells in Wnt signaling within the intestine and reports no new experimental results; the authors emphasize the relevance for conditions like inflammatory bowel diseases.
April 2023 in “Journal of Investigative Dermatology” This study found that LSD1 is crucial for embryonic skin barrier formation in mice, revealing its significant role in epidermal development and suggesting its potential as a target in skin diseases with barrier defects.
106 citations
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November 2014 in “Cell Stem Cell” This review discusses advanced techniques for investigating stem cell fate at the single-cell level, including lineage tracing, time-lapse imaging, and molecular profiling, but reports no new research results.
January 2013 in “International Journal of Trichology” This case report highlights the discovery of a novel TRPS1 gene mutation in a 17-year-old with TRPS type I, underscoring the diagnostic importance of hair symptoms in congenital hair diseases.
2 citations
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May 2011 in “Pigment Cell & Melanoma Research” In this study, Tanimura et al. reported that loss of collagen XVII in mice leads to hair loss and pigmentation defects, potentially due to impaired TGF-beta signaling affecting melanocyte stem cell maintenance.
10 citations
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May 2020 in “International Journal of Molecular Sciences” This study suggests that human hair follicles may serve as a model for molecular analysis of ABCA4 gene splice-site variants, facilitating research into the pathogenicity of ABCA4 retinopathies.
2 citations
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January 2020 in “Skin Appendage Disorders” This report presents a case where multiple steatocystomas appeared in a psoriatic patient during ustekinumab treatment, suggesting the drug may unmask a genetic predisposition to steatocystoma multiplex.
19 citations
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May 2016 in “Cytotechnology” 92 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” This study reports that human hair follicle stem cells express different surface markers than mouse stem cells, facilitating their isolation and potentially aiding in the development of cell-based skin treatments.
88 citations
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August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
1 citations
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March 2022 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that HIF-P4H-2 function in FoxD1-lineage cells is crucial for normal hair follicle development and homeostasis in mice, implicating disrupted HIF, TGF-β, and Notch signaling pathways in associated defects.
April 2026 in “Stem Cell Reviews and Reports” May 2022 in “The journal of immunology/The Journal of immunology” This study developed a foxn1-deficient Xenopus laevis model using CRISPR/Cas9, observing reduced T-cell markers and altered immune responses in tadpoles, providing a nonmammalian model for immunological research.
This study found that deleting the Twist1 gene in skin keratinocytes significantly reduced UVB-induced skin cancer and hyperproliferation in mice and suggested Twist1 as a target for skin cancer prevention.
April 2012 in “Development” This study found that Rac1 activity in specific skin compartments is sufficient for hair formation, but results in hair with altered structure and pigmentation compared to normal.
July 2026 in “Journal of Investigative Dermatology” Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.
13 citations
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January 2018 in “Advances in experimental medicine and biology” 43 citations
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December 2017 in “BMC Plant Biology” This study found that strigolactone biosynthesis and signaling components in soybean may interact with other hormone pathways, influencing soybean development and nodulation.
January 2024 in “Wiadomości Lekarskie” In this study, researchers developed a novel computational framework using deep reinforcement learning to identify strategies for cellular reprogramming in gene regulatory networks, showing its effectiveness in a model of immune response against infection.
22 citations
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April 2004 in “Journal of Neurochemistry” In this study, acute restraint stress increased Y1 receptor gene expression in the amygdala and PVN of transgenic mice, but this effect was not due to elevated neuroactive steroid concentrations, indicating a potential ligand-induced mechanism.
7 citations
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February 2009 in “Cell and tissue biology” July 2025 in “Journal of Investigative Dermatology” Hhip-Cre effectively targets dermal papilla cells for gene manipulation in hair biology.
November 2025 in “Journal of Investigative Dermatology” Disrupted cell interactions in hair follicles contribute to hair loss in androgenetic alopecia.
43 citations
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September 2009 in “Stem Cells” This study reported that GFP labeling driven by the K15 promoter enables visualization and selection of stem cells in adult human scalp hair follicles for further analysis and manipulation.
December 2019 in “Reproduction Fertility and Development” This study found that mouse embryonic fibroblasts better supported the growth and maintenance of LGR5+ epidermal stem cells compared to porcine fetal fibroblasts, under various culture conditions.
April 2017 in “Journal of Investigative Dermatology” Deleting Crif1 in mouse skin disrupts skin balance and hair growth.
53 citations
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April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.
80 citations
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September 2007 in “Cell Cycle” This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that in live rodents, actin filaments adjust their structure to facilitate membrane transfer between cellular compartments; linear filaments stabilize fused membranes, while branched filaments, connected by the protein Ezrin, drive integration, demonstrating actin's role in adapting to membrane biophysical changes.