The Role of Twist1 in UVB-Induced Skin Carcinogenesis

December 2020

Fernando Eguiarte‐Solomon

Twist1 UVB-induced skin carcinogenesis keratinocytes epidermal hyperproliferation keratinocyte differentiation hair follicle stem/progenitor markers Harmine

TLDR Deleting Twist1 in skin cells reduces UVB-induced skin cancer risk.

The study investigated the role of the transcription factor Twist1 in UVB-induced skin carcinogenesis using Twist1 knockout (KO) mice. It was found that deletion of Twist1 in skin keratinocytes significantly suppressed UVB-induced skin cancer by reducing epidermal hyperproliferation and promoting keratinocyte differentiation. Twist1 KO led to decreased proliferation, as shown by Ki67 and BrdU staining, and increased expression of differentiation markers such as TG1, K1, OVOL1, Loricrin, and Filaggrin. Overexpression of Twist1 suppressed differentiation, while its deletion depleted hair follicle stem/progenitor markers like CD34, Lrig1, Lgr5, and Lgr6. The study also identified Harmine as a compound that degrades Twist1, inhibiting UVB-induced proliferation and promoting differentiation. These findings suggested that Twist1 played a crucial role in regulating proliferation, differentiation, and self-renewal in the epidermis, highlighting its potential as a target for skin cancer prevention.

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