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Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Patients need long-term care after bariatric surgery to manage potential nutritional and metabolic issues.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Oestrogens are key for bone growth during puberty in both boys and girls.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Low iron levels may be linked to some types of hair loss in women.

Researchers developed a new model for more realistic computer graphics rendering of hair by considering how light scatters on hair fibers.

Blocking JAK-STAT signaling can lead to hair growth.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.