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Both estrogens and androgens are important for health in both males and females.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Skin-derived stem cells can become various cell types, including germ cell-like and oocyte-like cells.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

Various treatments, including FDA-approved drugs, natural products, and oral supplements, can help with hair loss, but a patient's medical history and potential allergies should be considered when choosing a treatment.

Metformin effectively improves metabolic symptoms in women with PCOS, while alfacalcidiol does not have a significant impact.

Women with PCOS have lower amylin levels, which are not related to their body weight.

Finasteride and metformin both help treat PCOS, but using them together works best.

Spironolactone effectively reduces symptoms of hyperandrogenism but has some side effects.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

Women with PCOS are more likely to have fatty liver disease, especially if they have metabolic problems.

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.

Ovarian SAHA syndrome makes women with PCOS more resistant to insulin and increases their risk of blood sugar problems.

Teens with PCOS and a mom with PCOS have higher insulin resistance and lower adiponectin levels, which could signal early metabolic problems.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.