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Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Cannabinoid and steroid-based drugs could be new treatments for Tourette syndrome, but more research is needed to confirm their effectiveness and safety.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Paeoniflorin protects brain cells by involving a specific protein and neurosteroids.

Pregnancy with Cushing's syndrome is rare and risky for both mother and baby, needing early diagnosis and treatment.

Most dogs with adrenal-dependent hypercortisolism had normal blood pressure after one year of treatment or surgery.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Certain drugs change freshwater snail shells to a "banana" shape.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.

The effects of estrogen on human scalp hair growth are unclear and need more research.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.

Certain drugs that block specific enzymes can help treat prostate diseases.

Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.