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The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

The enzyme PST is found in developing human kidneys and helps with detoxification and development.

Hormonal changes during and after pregnancy can cause hair growth changes and hair loss, with treatments available for some conditions.

Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Some skin diseases and their treatments can negatively affect male fertility.

The document emphasizes the importance of correctly identifying and classifying genetic hair disorders to help diagnose related health conditions.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

Obesity may contribute to female hair loss by increasing male hormone levels that affect hair follicles.

Frontal Fibrosing Alopecia might be an autoimmune disease.

Testosterone can both promote hair growth and cause baldness by affecting hair growth signals.

Telogen Effluvium is a hair loss condition where treatment involves identifying and managing its triggers.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Sebum production varies by individual and is influenced by age, gender, and hormones, affecting skin and hair health.

Understanding skin structure and development helps diagnose and treat skin disorders.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

The chapter explains that there are many genetic skin disorders affecting skin cell formation, including both common and rare types.

The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

Thyroid hormone may be useful for treating various skin conditions and needs more research.

High aldosterone and free testosterone levels link to female hair loss; testing aldosterone may predict hypertension risk.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.

Muscles can make their own androgens, which may help muscle growth.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.